| Gene Symbol | LIPA |
| Protein Type | Enzyme |
| Function | LIPA encodes lysosomal acid lipase (LIPA or LAL), a crucial enzyme that hydrolyzes cholesteryl esters and triglycerides in the lysosome. |
| Primary Expression | neurons, astrocytes, and microglia, with particular importance in lipid-rich region |
| Pathways | Cholesterol, Alpha-Synuclein, Lipid Metabolism, Phagocytosis, Apoptosis |
| Ensembl ID | ENSG00000107796 |
| GeneCards | LIPA |
| Human Protein Atlas | LIPA |
| Cholesteryl ester hydrolysis | Converting cholesteryl esters to free cholesterol and fatty acids |
| Triglyceride catabolism | Breaking down triglycerides for energy utilization |
| Lipoprotein processing | Essential for chylomicron and LDL metabolism |
| Autophagic flux | Involved in lipid droplet degradation via autophagy |
| Associated Diseases | ALS, Alzheimer, lipid droplet accumulation |
| Interactions | ABCA1, Actin, AGING, ALPHA-SYNUCLEIN, APOE, ATG |
| KG Connections | 168 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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