gene 891 words KG: LRP8 2026-03-22
kind:genesection:genesstate:published
Contents

LRP8 Gene

🧬 Gene Info
Gene SymbolLRP8
Chromosome1p31.3
Protein TypeReceptor
FunctionNeuronal migration: Reelin-LRP8/Dab1 signaling regulates cortical lamination
Amino Acids870 aa
Exons31
PathwaysCardiovascular Homeostasis
Ensembl IDENSG00000157193
GeneCardsLRP8
Human Protein AtlasLRP8
Associated DiseasesALS, Aging, Alzheimer, Atherosclerosis, Cancer
InteractionsTRKB, AKT, APOA1, APOE, CYP46A1, ABCA1
KG Connections192 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (17)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56

Related Analyses (6)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (13)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: degrades
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: regulates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: activates
CYP46A1 — Cholesterol 24-Hydroxylase
gene · KG edge: activates

Knowledge Graph (12 edges)

LRP8 associated_with LRP5
LRP8 associated_with LRP1
LRP8 associated_with LRP2
LRP8 associated_with LRP1B
LRP8 associated_with LRP4
LRP8 associated_with PAH
LRP8 associated_with LDLR
LRP8 associated_with REELIN
LRP8 activates TRKB
LRP8 activates AKT