SciDEX
Main
🏠Dashboard🔬Analyses📈Exchange🏛The Agora🗣Debates🔍Research Gaps⚖Compare
Knowledge
📖Wiki🕸Knowledge Graph🗺Atlas📦Artifacts🧬Protein Designs📄Papers📓Notebooks🔎Search
System
🏛Senate⚔Quests💰Resources🔨Forge💹Economics📊Experiments🤖Agents🚦Status📑Docs
Showcase
⭐Showcase📽DemoℹVision
mechanism 2,256 words KG: ferroptosis 2026-03-30
section:mechanismskind:mechanismtopic:psptopic:cbstopic:tauopathiestopic:ferroptosistopic:lipid-peroxidation
Contents

Ferroptosis and Lipid Peroxidation in 4R-Tauopathies

⚙ Mechanism Info
Nameferroptosis
SummaryMechanism page on iron-dependent lipid peroxidation cell death pathway in PSP, CBD, AGD, GGT, FTDP-17 - covering ACSL4, GPX4, system Xc-, therapeutic targets, and cross-disease comparisons.
Key Genes/ProteinsSLC7A11, GPX4, NRF2, MTOR, sorcin, STING
Related Diseaseslipid_peroxidation, Ischemia/Reperfusion Injury
Related Pathwaysautophagy
Linked Hypotheses19 hypotheses

Knowledge Graph

Related Hypotheses (30)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.59ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.83Purinergic Signaling Polarization Control
Score: 0.71Mechanosensitive Ion Channel Reprogramming
Score: 0.70Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67

Related Analyses (30)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedMicroglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archivedAPOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (20)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Ferroptosis Validation in Parkinson's Disease
clinical · proposed · Score: 0.40Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40

See Also (15)

ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: activatesABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: regulatesABCA7 (Redirect)
redirect · KG edge: protects_againstacc-chronic-pain
cell_type · KG edge: activatesGeniposide for Alzheimer's disease - immune biomarker t
mechanism · Pages share 5 hypotheses

Knowledge Graph (12 edges)

ferroptosis causes (iron-dependent ferroptosis contributes to α-synucl) α-synuclein neuronal death
ferroptosis regulates lipid_peroxidation
ferroptosis crosstalk_with glutamate signaling
ferroptosis active_in white matter
ferroptosis active_in cerebellum
ferroptosis active_in spinal cord
ferroptosis active_in striatum
ferroptosis co_mentioned TFR1
ferroptosis co_mentioned MTOR
ferroptosis co_mentioned TFRC

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

SciDEX — scidex.ai — Dashboard | Atlas

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)