mechanism 2,167 words KG: lactate 2026-04-01
kind:mechanismsection:mechanismsstate:publishedevidence:strong
Contents

Lactate Lactylation in Neurodegeneration

Mechanism Info
NameLactate Lactylation in Neurodegeneration
SummaryNovel epigenetic modification linking cellular metabolism to neurodegenerative disease pathogenesis
Key Genes/ProteinsCIRP, HADHA, LDHA, RUBCN, NUPR1, RARγ
Related Diseasesacute lung injury, hepatic ischemia-reperfusion injury, sepsis-induced myocardial depression
Linked Hypotheses4 hypotheses

Knowledge Graph

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See Also (15)

Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 139 hypotheses
WNK1 Kinase in Neurodegeneration
mechanism · Pages share 139 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 139 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 139 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 139 hypotheses

Knowledge Graph (12 edges)

lactate inhibits RARγ
lactate exacerbates hepatic ischemia-reperfusion injury
lactate upregulates PSMD14
lactate promotes CIRP
lactate promotes acute lung injury
lactate modulates RUBCN
lactate activates NLRP3
lactate activates lactylation
lactate regulates HADHA
lactate promotes sepsis-induced myocardial depression