mechanism 1,807 words KG: ent-gene-c9882297 2026-04-01
kind:mechanismsection:mechanismsstate:published
Contents

MS4A4A-MS4A6A Cooperation in TREM2 Regulation

🔬 Protein Info
Gene SymbolMS4A4A
Full NameMS4A6A Cooperation in TREM2 Regulation
AliasesMembrane-Spanning 4-Domains A4A
Chromosome11q12.2
Functionencodes a membrane protein expressed primarily in immune cells, particularly microglia and other myeloid cells.
Primary Expressionimmune cells, particularly microglia and other myeloid cells
Molecular Weight24 kDa
Amino Acids199 aa
Exons6
UniProt IDQ9H3Y1
NCBI Gene ID246213
Ensembl IDENSG00000166926
OMIM614508
GeneCardsMS4A4A
Human Protein AtlasMS4A4A
Associated DiseasesAlzheimer's disease, Cancer
InteractionsMS4A6A, MS4A6E, TREM2, APOE, CLU, CR1
KG Connections54 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegen
Score: 0.64
TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegene
Score: 0.61
TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegener
Score: 0.61
TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming
Score: 0.59
TREM2-SIRT1 Metabolic Senescence Circuit in Microglial Aging
Score: 0.59

Related Analyses (30)

TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · failed
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · archived
Immune atlas neuroinflammation analysis in neurodegeneration
Neuroinflammation · archived
Immune atlas neuroinflammation analysis in neurodegeneration
Neuroinflammation · completed
Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archived

Related Experiments (6)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.40
TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.40
TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.40

See Also (7)

TREM2 Gene-Mechanism-Therapy Chain — From Genetic Risk
mechanism · Pages share 3 hypotheses
TREM2 in Frontotemporal Dementia
mechanism · Pages share 3 hypotheses
TREM2 in Amyotrophic Lateral Sclerosis
mechanism · Pages share 3 hypotheses
TREM2 Gene
gene · Pages share 3 hypotheses
al002-trem2-agonist-alzheimers
clinical_trial · Pages share 3 hypotheses

Knowledge Graph (2 edges)

ent-gene-c9882297 data_in benchmark_ot_ad_answer_key:MS4A4A
benchmark_ot_ad_answer_key:MS4A4A data_in ent-gene-c9882297