protein 1,982 words KG: NQO1
Contents

NQO1 Protein (NAD(P)H Quinone Dehydrogenase 1)

🔬 Protein Info
Gene SymbolNQO1
Full NameNAD(P)H Quinone Dehydrogenase 1
AliasesNAD(P
Chromosome16q22.1
FunctionNQO1 uses NAD(P)H as an electron donor to reduce quinones, preventing the formation of toxic semiquinone radicals.
Subcellular Localization** | Cytoplasm, also nucleus (minor) |
Molecular Weight31 kDa
Amino Acids274 aa
PathwaysApoptosis, Ferroptosis
UniProt IDP15559
NCBI Gene ID1728
Ensembl IDENSG00000100119
OMIM125860
GeneCardsNQO1
Human Protein AtlasNQO1
Associated DiseasesInflammation, Senescence
InteractionsAKT, ALZHEIMER, ALZHEIMER'S DISEASE, AND, ANTIOXIDANT GENES, APOPTOSIS
KG Connections280 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (2)

NRF2 failure lowers antioxidant reserve and permits recurren
Score: 0.74
FSP1/CoQ10 Axis as GPX4-Independent Neuroprotective Pathway
Score: 0.48

Knowledge Graph (12 edges)

NRF2 regulates NQO1
NQO1 regulates HMOX1
NQO1 regulates TXNRD1
NQO1 regulates NRF2
NQO1 regulates GCLM
NQO1 regulates GCLC
NQO1 activates GCLC
NQO1 activates TNF
NQO1 activates PI3K
NQO1 activates NRF2

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