gene 587 words KG: TXNRD1 2026-03-24
kind:genesection:genesstate:published
Contents

TXNRD1 — Thioredoxin Reductase 1

🧬 Gene Info
Gene SymbolTXNRD1
Full NameThioredoxin Reductase 1
Chromosome12q23.3
Protein TypeGene
Functionis an important component in the neurobiology of neurodegenerative diseases.
Amino Acids500 aa
PathwaysDna Methylation
UniProt IDQ16881
NCBI Gene ID7296
Ensembl IDENSG00000198431
GeneCardsTXNRD1
Human Protein AtlasTXNRD1
Associated DiseasesALS, Alzheimer, Inflammation, Macular Degeneration, depression
InteractionsAPP, TAU, TRKB, BDNF, TPH2, NGF
KG Connections126 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.51
Autophagosome Maturation Checkpoint Control
Score: 0.49
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.45

Related Analyses (3)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Sirtuin Pathway Dysfunction Validation in Parkinson's Diseas
clinical · proposed · Score: 0.40

See Also (15)

Mitophagy Receptor Pathway in Neurodegeneration
mechanism · KG edge: causes
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: inhibits
Packard Center for ALS Research
institution · KG edge: expressed_in
Alzheimer Indonesia
institution · KG edge: expressed_in
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates

Knowledge Graph (12 edges)

TXNRD1 regulates NRF2
TXNRD1 regulates GCLM
TXNRD1 regulates GCLC
TXNRD1 regulates MFN2
TXNRD1 associated_with UNG
TXNRD1 regulates SDHB
TXNRD1 activates APP
TXNRD1 activates TAU
TXNRD1 activates TRKB
TXNRD1 activates BDNF