| Gene Symbol | PHF6 |
| Full Name | PHD Finger Protein 6 |
| Function | This allows PHF6 to function as a "reader" of the histone code, translating epigenetic marks into transcriptional outcomes. |
| Primary Expression | human tissues, with high expression in the brain, particularly during development |
| Subcellular Localization | **Nucleus**: Predominantly nuclear, with enrichment in certain nuclear compartments |
| Molecular Weight | 76 kDa |
| Ensembl ID | ENSG00000156500 |
| GeneCards | PHF6 |
| Human Protein Atlas | PHF6 |
| PHD Zinc Finger Domains | Two PHD-type zinc fingers at the C-terminus that function as epigenetic reader modules |
| N-terminal Region | Contains regions of low complexity and potential regulatory sequences |
| Nuclear Localization | The protein contains nuclear localization signals that target it to the nucleus |
| Nucleus | Predominantly nuclear, with enrichment in certain nuclear compartments |
| Chromatin-associated | Direct association with chromatin |
| Cell type variability | Localization patterns may vary across cell types |
| Associated Diseases | neurodegeneration |
| Interactions | LRP1 |
| KG Connections | 15 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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