| Gene Symbol | PLK4 |
| Full Name | Polo-Like Kinase 4 |
| Chromosome | 4q28.1 |
| Protein Type | Kinase |
| Function | is a serine/threonine protein kinase that serves as the master regulator of centriole duplication, playing a critical role in microtubule organization, ciliogenesis, and cell cycle progression. |
| Primary Expression | the central nervous system: |
| Molecular Weight | 97 kDa |
| Ensembl ID | ENSG00000142792 |
| GeneCards | PLK4 |
| Human Protein Atlas | PLK4 |
| Centriole Duplication | Acts as the master regulator ensuring one centriole per cell cycle |
| Kinase Activity | Phosphorylates downstream targets to promote centriole formation |
| Cell Cycle Regulation | Controls G1/S transition and mitotic entry |
| Ciliogenesis | Required for primary cilia formation in interphase cells |
| [STIL](/genes/stil) | Critical co-factor for centriole duplication |
| Associated Diseases | Alzheimer, Parkinson |
| Interactions | FCGRT, KAT2A |
| KG Connections | 31 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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