| Gene Symbol | FCGRT |
| Full Name | Fc fragment of IgG receptor and transporter |
| Chromosome | 19q13.33 |
| Protein Family | transporter |
| Target Class | Transporter |
| Function | functions as a neonatal Fc receptor (FcRn), responsible for the bidirectional transport of immunoglobulin G (IgG) across epithelial and endothelial barriers |
| Mechanism of Action | Monoclonal antibody blocking FcRn-mediated IgG recycling |
| Primary Expression | midbrain, Cortex, Hippocampus, Cerebellum |
| Druggability | Medium (0.51) |
| Clinical Stage | Approved |
| Pathways | Lysosomal Degradation, Blood-Brain Barrier, neuroinflammation, Neuroinflammatory, Neonatal Fc receptor / antibody transcytosis |
| GeneCards | FCGRT |
| Human Protein Atlas | FCGRT |
| β2-microglobulin | Essential cofactor for FCGRT function |
| Blood-brain barrier (BBB) | Primary site of FCGRT-mediated immune surveillance |
| Associated Diseases | Alzheimer, Ivig Effectiveness, Myasthenia Gravis, Parkinson, neurodegeneration, schizophrenia |
| Known Drugs/Compounds | TfRMAb-TNFR, TfRMAb-EPO, Tfrmab, Humanized Monoclonal Antibodies, TfRMAb fusion protein, Tfrmab-Tnfr |
| Interactions | PLK4, TYROBP, SARS, TMPRSS2, Fc Domain, C1QA |
| SciDEX Target | View Target Profile (6 clinical trials) |
| SciDEX Hypotheses | Dual-Domain Antibodies with Engineered Fc-FcRn Aff |
| KG Connections | 217 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |