protein 1,048 words KG: ATG12PROTEIN 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

ATG12 Protein (Autophagy-related Protein 12)

🔬 Protein Info
Gene SymbolATG12
Full NameAutophagy-related Protein 12
AliasesATG12PROTEIN
Chromosome5q21.2
Protein FamilyATG12 family
Functionis a ubiquitin-like protein that plays an essential role in autophagy, the cellular process for degrading and recycling damaged organelles and proteins.
Subcellular LocalizationCytoplasm, autophagosome membrane
Molecular Weight17 kDa
PathwaysAutophagy, Cell Cycle, Mitophagy
UniProt IDO95166
NCBI Gene ID9459
Ensembl IDENSG00000181458
GeneCardsATG12
Human Protein AtlasATG12
GeneATG12
Associated DiseasesAls, Alzheimer, Ataxia, Infection, Ms, Neurodegeneration
Known Drugs/Compoundsrapamycin
InteractionsSTUB1, PPARGC1A, TARDBP, TREH, BECN1, GAPDH
KG Connections471 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (9)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Circadian Clock-Autophagy Synchronization
Score: 0.55
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
VCP-Mediated Autophagy Enhancement
Score: 0.41

Related Analyses (11)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (1)

Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in