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protein 682 words KG: C5
Contents

C5 Protein

🔬 Protein Info
Gene SymbolC5
Chromosome9q34.1
Protein FamilyComplement system
FunctionThe C5 gene encodes a component of the complement system, part of the innate immune system involved in inflammation and immune response.
Subcellular LocalizationPlasma
Molecular Weight190 kDa
PathwaysMembrane Attack Complex
UniProt IDP01031
GeneCardsC5
Human Protein AtlasC5
Associated Diseasesneurodegeneration
InteractionsAQP4, C3, CD19, CR1
KG Connections34 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (18)

Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62SASP-Mediated Complement Cascade Amplification
Score: 0.82SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76Senescence-Activated NAD+ Depletion Rescue
Score: 0.76Senescent Cell Mitochondrial DNA Release
Score: 0.74Aquaporin-4 Polarization Rescue
Score: 0.73Senescence-Associated Myelin Lipid Remodeling
Score: 0.73Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73Microglial Purinergic Reprogramming
Score: 0.70Complement C1q Subtype Switching
Score: 0.66Glial Glycocalyx Remodeling Therapy
Score: 0.65Ephrin-B2/EphB4 Axis Manipulation
Score: 0.64Sphingolipid Metabolism Reprogramming
Score: 0.62Netrin-1 Gradient Restoration
Score: 0.59

Related Analyses (10)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedSenolytic therapy for age-related neurodegeneration
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (12)

Neurodegeneration
disease · KG edge: implicated_inAQP4 (Aquaporin-4 Gene)
gene · KG edge: inhibitsBIN1 — Bridging Integrator 1
gene · KG edge: causesC1QA Gene — Complement Component 1q A Chain
gene · KG edge: co_discussedC3 — Complement Component 3
gene · KG edge: activates

Knowledge Graph (12 edges)

C5 mediates Membrane Attack Complex Stress
C3 co_discussed C5
C1Q co_discussed C5
C5 co_discussed CR1
C5 involved_in Membrane Attack Complex
C5 involved_in Membrane Attack Complex Stress
AQP4 inhibits C5
C5 inhibits CD19
C3 activates C5
C5 participates_in complement cascade

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