protein 675 words KG: CD68PROTEIN
Contents

CD68 Protein (Macrosialin)

🔬 Protein Info
Gene SymbolCD68
Full NameCluster of Differentiation 68
AliasesMacrosialin
Chromosome17p13.1
FunctionCD68 is a member of the lysosomal-associated membrane protein (LAMP) family:
Primary Expressionmonocytes and macrophages
Amino Acids22 aa
PathwaysGlial Phagocytosis
NCBI Gene ID968
Ensembl IDENSG00000129226
OMIM609453
GeneCardsCD68
Human Protein AtlasCD68
N-terminal leader peptide20-22 amino acids
Large mucin-like domainContains multiple O-linked glycosylation sites
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease, cancer
InteractionsABCA1, ACSL4, Actin, AGING, AIF1, AKT
KG Connections688 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

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UniProtWikipedia

Related Hypotheses (12)

Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE-TREM2 Interaction Modulation
Score: 0.74
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Extracellular Matrix Stiffness Modulation
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-Dependent Microglial Senescence Transition
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

Related Experiments (15)

Chi3l1 deletion in APP/PS1 mouse model of Alzheimer's diseas
validation · proposed · Score: 0.95
TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.45
Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.45
s:** - ALOX15 overexpression in healthy astrocytes should be
falsification · proposed · Score: 0.40
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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