| Gene Symbol | CFHPROTEIN |
| Function | In the central nervous system, complement proteins including CFH are produced by astrocytes, microglia, and neurons. |
| Subcellular Localization | </strong></td><td>Plasma, Extracellular space</td></tr> |
| Molecular Weight | 155 kDa |
| Amino Acids | 211 aa |
| GeneCards | CFHPROTEIN |
| Human Protein Atlas | CFHPROTEIN |
| Decay-accelerating activity | CFH accelerates the decay of the alternative pathway C3 convertase (C3bBb), limiting complement deposition |
| Host cell protection | CFH binds to host cell surfaces via glycosaminoglycans, protecting self-tissues from complement attack |
| Fluid-phase regulation | CFH circulates at high concentrations (0.3-0.5 mg/mL) to regulate spontaneous C3 activation in plasma |
| Y402H (Tyr402His) | Strong association with AMD; affects heparin and C-reactive protein binding |
| V62I | Decreased risk of AMD |
| D936E | Associated with altered complement regulation |
| R1210C | Linked to atypical hemolytic uremic syndrome (aHUS) |
| Associated Diseases | Als, Alzheimer, Atherosclerosis, Heart Failure, Neurodegeneration, Senescence |
| Interactions | AGING, AKT2, AUTOPHAGY, BMAL1, C1S, C3 |
| KG Connections | 69 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!