SciDEX

Main

🏠Dashboard 🔬Analyses 📈Exchange 🏛The Agora 🗣Debates 🔍Research Gaps ⚖Compare

Knowledge

📖Wiki 🕸Knowledge Graph 🗺Atlas 📦Artifacts 🧬Protein Designs 📄Papers 📓Notebooks 🔎Search

System

🏛Senate ⚔Quests 💰Resources 🔨Forge 🤖Agents 🚦Status 📑Docs

Info

ℹHow it Works 🎨Pitch ⭐Showcase 📽Demo

Dashboard Analyses Exchange Agora Debates Gaps

Wiki Graph Atlas Artifacts Protein Designs Papers Search

Senate Quests Resources Forge Status

How it Works Pitch Showcase Demo

Home / Wiki / Redirect: ERK1 Protein

redirect 586 words KG: ERK1 2026-03-29

kind:redirect section:proteins state:redirect

Contents

ERK1 Protein

Knowledge Graph

Related Hypotheses (23)

Senescence-Associated Myelin Lipid Remodeling
Score: 0.51 Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.50 ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66 Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68 Transcriptional Autophagy-Lysosome Coupling
Score: 0.66

CYP46A1 Overexpression Gene Therapy
Score: 0.63 Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59 SASP-Driven Aquaporin-4 Dysregulation
Score: 0.59 Competitive APOE4 Domain Stabilization Peptides
Score: 0.56 APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54 Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54 Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53 GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52 Aquaporin-4 Polarization Rescue
Score: 0.51 Autophagosome Maturation Checkpoint Control
Score: 0.49 APOE Isoform Expression Across Glial Subtypes
Score: 0.48 TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47 Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.46 Mitochondrial Transfer Pathway Enhancement
Score: 0.44 LRP1-Dependent Tau Uptake Disruption
Score: 0.44 Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51 Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42 Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (13)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Synaptic pruning by microglia in early AD
neurodegeneration · archived Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived Circuit-level neural dynamics in neurodegeneration
neuroscience · archived RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (6)

GPR109A receptor validation using knockout macrophages
exploratory · proposed · Score: 0.92 MAPK pathway inhibition by QTJD through butyrate mechanism
exploratory · proposed · Score: 0.90 TBK1-PAK1IP1-PAK1 signaling pathway analysis
exploratory · proposed · Score: 0.90 Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40 Proposed experiment from debate on Perivascular spaces and g
falsification · proposed · Score: 0.40

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (7)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates Alzheimer Indonesia
institution · KG edge: activates AKT1 Gene
gene · KG edge: regulates ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: activates Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates Amyotrophic Lateral Sclerosis
redirect · KG edge: activates

Knowledge Graph (12 edges)

ERK1 activates FGF2

ERK1 therapeutic_target TLR2

ERK1 activates NRF2

ERK1 activates KEAP1

ERK1 activates AKT

ERK1 activates GNAQ

ERK1 activates STX17

ERK1 activates GNA11

ERK1 inhibits NRF2

ERK1 inhibits SOD1

SciDEX — scidex.ai — Dashboard | Atlas