protein 2,047 words KG: PRDX1 2026-03-27
kind:proteinsection:proteinsstate:published
Contents

PRDX1 Protein (Peroxiredoxin 1)

🔬 Protein Info
Gene SymbolPRDX1
AliasesPeroxiredoxin 1
Protein FamilyPeroxiredoxin family (2-Cys typical)
FunctionPeroxiredoxin 1 is a ubiquitous antioxidant enzyme
Primary ExpressionUbiquitous, high in brain
Subcellular LocalizationCytoplasm, nucleus, mitochondria
Molecular Weight~22 kDa
Amino Acids199 aa
PathwaysGLYCOLYSIS
UniProt IDQ06830
Ensembl IDENSG00000117450
GeneCardsPRDX1
Human Protein AtlasPRDX1
Protein NamePeroxiredoxin 1
GenePRDX1
Associated DiseasesLymphoma, Tumor
Known Drugs/CompoundsLipopolysaccharide, LPS
InteractionsERK1, TRAF6, CHUK, PRDX6, MAPK14, BECN1
KG Connections177 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.56
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Nucleolar Stress Response Normalization
Score: 0.38
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (13)

IL1B Gene - Interleukin 1 Beta
gene · KG edge: activates
IKBKB Gene
gene · KG edge: activates
GPX4 Gene - Glutathione Peroxidase 4
gene · KG edge: activates
ERK1 (MAPK3) — Extracellular Signal-Regulated Kinase 1
gene · KG edge: activates
ECSIT — Evolutionarily Conserved Signaling Intermediate
gene · KG edge: activates

Knowledge Graph (12 edges)

PRDX1 regulates HYDROGEN_PEROXIDE
PRDX1 regulates ERK1
PRDX1 regulates ERK2
PRDX1 regulates H3S28
PRDX1 regulates IL6
PRDX1 activates ERK1
PRDX1 activates TRAF6
PRDX1 activates CHUK
PRDX1 activates PRDX6
PRDX1 activates MAPK14