protein 2,239 words KG: GRIN2A 2026-03-23
kind:proteinsection:proteinsstate:published
Contents

GRIN2A Protein

🔬 Protein Info
Gene SymbolGRIN2A
AliasesNMDA Receptor Subunit 2A
Functionregulation implicated in Alzheimer's
Primary ExpressionPrefrontal Cortex, Cortex, Hippocampus
Subcellular Localizationsynaptic sites
Molecular Weight180 kDa
Amino Acids838 aa
PathwaysNF-κB
GeneCardsGRIN2A
Human Protein AtlasGRIN2A
Extracellular NTDAgonist binding
Ligand-binding domainGlutamate, glycine
Transmembrane domainsIon pore
C-terminal domainSynaptic localization
CompoundMechanism
Associated DiseasesAlzheimer, schizophrenia
Known Drugs/CompoundsGW201
InteractionsKCNIP4, NLGN1, AQP4, NCAM2, APP, RORB
KG Connections144 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

APOE-Dependent Autophagy Restoration
Score: 0.61
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35
Synaptic Vesicle Tau Capture Inhibition
Score: 0.34

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

Dementia Australia
institution · KG edge: expressed_in
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
Glutamate Decarboxylase 1
gene · KG edge: biomarker_for
FGF14 — Fibroblast Growth Factor 14
gene · KG edge: activates

Knowledge Graph (12 edges)

GRIN2A co_discussed SNAP25
GRIN2A activates KCNIP4
GRIN2A co_discussed NCAM2
GRIN2A co_discussed NRXN1
GRIN2A co_discussed RORA
GRIN2A biomarker_for PVALB
GRIN2A biomarker_for SNAP25
GRIN2A activates NLGN1
GRIN2A activates AQP4
GRIN2A biomarker_for GAD1