gene 1,848 words KG: RORB
Contents

RORB Gene

🧬 Gene Info
Gene SymbolRORB
Full NameRAR-Related Orphan Receptor Beta
Chromosome9q21.2
Protein FamilyNuclear receptor, ROR subfamily
Protein TypeReceptor
Functionencodes a nuclear receptor protein that plays critical roles in circadian rhythm regulation, brain development, neuronal differentiation, and synaptic plasticity.
Primary ExpressionBrain (cortex, hippocampus, cerebellum, basal ganglia)
Amino Acids459 aa
PathwaysCircadian Rhythm, Nf-Κb
UniProt IDQ00978
NCBI Gene ID5876
Ensembl IDENSG00000143163
OMIM601925
GeneCardsRORB
Human Protein AtlasRORB
Associated DiseasesAging, Alzheimer
InteractionsActin, ALZHEIMER, ALZHEIMER'S DISEASE, APP, Fgf, FGF14
KG Connections89 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (20)

Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
APOE-Dependent Autophagy Restoration
Score: 0.89
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.88
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Circadian Clock-Autophagy Synchronization
Score: 0.76
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.71
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.61
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
Cryptic Exon Silencing Restoration
Score: 0.53

Related Analyses (6)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

NeuRon Therapeutics
company · KG edge: associated_with
Genes
index · KG edge: activates
CLOCK Gene
gene · KG edge: associated_with
CRY1 Gene
gene · KG edge: associated_with
FGF14 — Fibroblast Growth Factor 14
gene · KG edge: activates

Knowledge Graph (12 edges)

CRY1 associated_with RORB
MYD88 regulates RORB
CLOCK associated_with RORB
TLR2 regulates RORB
RORB regulates MYD88
RORB activates GRIN2A
RORB activates NCAM2
RORB activates NRXN1
RORB activates RORA
NRXN1 activates RORB

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.