gene 1,848 words KG: RORB 2026-03-26
kind:genesection:genesstate:published
Contents

RORB Gene

🧬 Gene Info
Gene SymbolRORB
Full NameRAR-Related Orphan Receptor Beta
Chromosome9q21.2
Protein FamilyNuclear receptor, ROR subfamily
Protein TypeReceptor
Functionencodes a nuclear receptor protein that plays critical roles in circadian rhythm regulation, brain development, neuronal differentiation, and synaptic plasticity.
Primary ExpressionBrain (cortex, hippocampus, cerebellum, basal ganglia)
Amino Acids459 aa
PathwaysCircadian Rhythm, Nf-Κb
UniProt IDQ00978
NCBI Gene ID5876
Ensembl IDENSG00000143163
OMIM601925
GeneCardsRORB
Human Protein AtlasRORB
Associated DiseasesAging, Alzheimer
InteractionsGRIN2A, NCAM2, NRXN1, RORA, KCNIP4, APP
KG Connections90 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (20)

Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.48
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
APOE-Dependent Autophagy Restoration
Score: 0.61

Related Analyses (6)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
ncam2
gene · KG edge: activates
MYD88 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

RORB regulates MYD88
RORB activates GRIN2A
RORB activates NCAM2
RORB activates NRXN1
RORB activates RORA
RORB activates KCNIP4
RORB activates APP
RORB activates FGF14
RORB activates NLGN1
RORB associated_with TAU