gene 914 words KG: GAD1 2026-03-24
kind:genesection:genesstate:published
Contents

Glutamate Decarboxylase 1

🧬 Gene Info
Gene SymbolGAD1
Full NameGlutamate Decarboxylase 1
Chromosome2q31.1
Protein TypeReceptor
FunctionIt plays critical roles in ciliary signaling, neuronal migration, and synaptic function.
Primary Expressionregions affected in Parkinson disease
PathwaysMapk, autophagy pathway
UniProt IDP23284
NCBI Gene ID2571
Ensembl IDENSG00000118592
OMIM605119
GeneCardsGAD1
Human Protein AtlasGAD1
Associated Diseasesepilepsy
Known Drugs/Compoundsrapamycin
InteractionsSST, TRKB, NTF3, CALB2, CALB1, PVALB
KG Connections190 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
APOE-Dependent Autophagy Restoration
Score: 0.61
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.59
Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.44
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.41

Related Analyses (3)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · completed
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

Related Experiments (4)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Microbiome-Gut-Brain Axis in Alzheimer's Disease — mechanism
clinical · proposed · Score: 0.40
Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40

See Also (12)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: expressed_in
Packard Center for ALS Research
institution · KG edge: expressed_in
Dementia Australia
institution · KG edge: expressed_in
Alzheimer Indonesia
institution · KG edge: expressed_in
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: co_discussed

Knowledge Graph (12 edges)

GAD1 co_discussed PSEN1
GAD1 biomarker_for SYP
GAD1 biomarker_for SLC32A1
GAD1 biomarker_for GRIN2A
GAD1 biomarker_for PVALB
GAD1 biomarker_for SNAP25
GAD1 associated_with PVALB
GAD1 inhibits SST
GAD1 inhibits TRKB
GAD1 activates NTF3