| Gene Symbol | HDAC1 |
| Aliases | HDAC1PROTEIN |
| Chromosome | 1p35.2-p35.1<br> |
| Function | HDAC1 functions as a transcriptional repressor by deacetylating histone H3 and H4 tails, leading to chromatin compaction and reduced gene expression. |
| Primary Expression | the brain with high levels in:
- Hippocampus (CA1-CA3 pyramidal neurons)
- Cerebral cortex (lay |
| Subcellular Localization | </strong></td><td>Nucleus</td></tr> |
| Molecular Weight | 55 kDa |
| Pathways | NF-κB |
| UniProt ID | Q13547 |
| NCBI Gene ID | 3065 |
| Ensembl ID | ENSG00000100994 |
| GeneCards | HDAC1 |
| Human Protein Atlas | HDAC1 |
| Associated Diseases | Alzheimer, disease, synaptic dysfunction |
| Known Drugs/Compounds | BORTEZOMIB |
| Interactions | JUN, TP53, CD8, AKT, MYC, PI3K |
| KG Connections | 345 knowledge graph edges |
| Databases | GeneCardsHPASTRING |