protein 1,933 words KG: HEPSIN 2026-03-28
kind:proteinsection:proteinsstate:published
Contents

Hepsin Protein

🔬 Protein Info
Gene SymbolHEPSIN
Chromosome19q13.12
Protein TypeProtease
Functionis a type II transmembrane serine protease (TTSP) that belongs to the family of trypsin-like serine proteases.
Primary Expressionvarious tissues, including the liver, kidney, and brain, where it plays important roles in extracellular matrix remodeling, cell growth, and signal tr
Amino Acids18 aa
GeneCardsHEPSIN
Human Protein AtlasHEPSIN
N-terminal cytoplasmic tail1-18 aa
Stem region41-250 aa
Protease domain251-417 aa
C-terminal domain418-480 aa
TissueExpression Level
LiverVery High
KidneyHigh
Associated Diseasesneurodegeneration
KG Connections102 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (26)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65
Microbial Inflammasome Priming Prevention
Score: 0.58
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53

Related Analyses (20)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived

Related Experiments (4)

s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40
Alpha-Synuclein Spreading Mechanism — Prion-Like Propagation
exploratory · proposed · Score: 0.40
Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40
TMEM106B Haplotype as Genetic Modifier in FTD — Mechanism an
validation · proposed · Score: 0.40

See Also (15)

Transdiagnostic Proteomic Changes in Neurodegeneration
mechanism · Pages share 8 hypotheses
Transdiagnostic Proteomic Changes in Neurodegeneration
mechanism · Pages share 8 hypotheses
Therapeutic Targets in Neurodegeneration
mechanism · Pages share 8 hypotheses
Sex Differences in Neurodegeneration
mechanism · Pages share 8 hypotheses
Senescent Cell Clearance in Neurodegeneration
mechanism · Pages share 8 hypotheses

Knowledge Graph (12 edges)

HEPSIN co_discussed SCRIB
HEPSIN co_discussed STING
HEPSIN co_discussed DDIT3
HEPSIN co_discussed CHOP
HEPSIN co_discussed DISC1
HEPSIN co_discussed DNM1L
HEPSIN co_discussed DRP1
HEPSIN co_discussed EIF2AK3
HEPSIN co_discussed PERK
HEPSIN co_discussed EIF2S1