gene 2,052 words KG: FGF21 2026-03-26
kind:genesection:genestopic:alzheimerstopic:parkinsonsstate:published
Contents

FGF21 — Fibroblast Growth Factor 21

🧬 Gene Info
Gene SymbolFGF21
Full NameFibroblast Growth Factor 21
Chromosome12q13
Functionencodes a member of the FGF19 subfamily of fibroblast growth factors that functions primarily as a metabolic regulator.
Molecular Weight22.5 kDa
Amino Acids209 aa
PathwaysApoptosis, Autophagy, Mtor
UniProt IDQ9NS73
NCBI Gene ID26291
Ensembl IDENSG00000163410
OMIM609436
GeneCardsFGF21
Human Protein AtlasFGF21
Associated DiseasesAging, Als, Alzheimer, Amyotrophic Lateral Sclerosis Survival, Diabetes, Fibrosis
Known Drugs/Compoundsmetformin
InteractionsULK1, KDM6B, LC3, ATG7, FNDC5, PLAU
KG Connections504 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (17)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.47
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.44
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68

Related Analyses (8)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived

Related Experiments (7)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40

See Also (11)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: biomarker_for
ATG7 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

FGF21 activates ULK1
FGF21 activates KDM6B
FGF21 activates LC3
FGF21 activates ATG7
FGF21 biomarker_for APP
FGF21 activates FNDC5
FGF21 biomarker_for S100B
FGF21 activates PLAU
FGF21 activates CXCL10
FGF21 biomarker_for C1Q