gene 2,052 words KG: FGF21
Contents

FGF21 — Fibroblast Growth Factor 21

🧬 Gene Info
Gene SymbolFGF21
Full NameFibroblast Growth Factor 21
Chromosome12q13
Functionencodes a member of the FGF19 subfamily of fibroblast growth factors that functions primarily as a metabolic regulator.
Molecular Weight22.5 kDa
Amino Acids209 aa
PathwaysApoptosis, Autophagy, Mtor
UniProt IDQ9NS73
NCBI Gene ID26291
Ensembl IDENSG00000163410
OMIM609436
GeneCardsFGF21
Human Protein AtlasFGF21
Associated DiseasesAging, Als, Alzheimer, Amyotrophic Lateral Sclerosis Survival, diabetes
Known Drugs/Compoundsmetformin
InteractionsACE2, Actin, AGING, AKT, ALOX15, ALZHEIMER
KG Connections498 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (17)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
APOE-Dependent Autophagy Restoration
Score: 0.89
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.83
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Transcriptional Autophagy-Lysosome Coupling
Score: 0.78
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62

Related Analyses (8)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived

Related Experiments (7)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (11)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: biomarker_for
ALDH1A1 Gene
gene · KG edge: associated_with
ALOX15 - Arachidonate 15-Lipoxygenase
gene · KG edge: activates

Knowledge Graph (12 edges)

FGF21 activates ULK1
FGF21 activates KDM6B
FGF21 activates LC3
FGF21 activates ATG7
FGF21 biomarker_for APP
FGF21 activates FNDC5
FGF21 biomarker_for S100B
FGF21 activates PLAU
FGF21 activates CXCL10
FGF21 biomarker_for C1Q

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