protein 980 words KG: HSP90AA1PROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

HSP90AA1 Protein

🔬 Protein Info
Gene SymbolHSP90AA1
Full NameHSP90AA1
Chromosome14q32.31
Protein TypeChaperone
Target ClassChaperone
FunctionSmall molecule inhibitor binding to ATP-binding pocket of chaperone
Mechanism of ActionSmall molecule inhibitor binding to ATP-binding pocket of chaperone
Subcellular Localization** Cytoplasm, Nucleus
DruggabilityLow (0.45)
Clinical StagePhase III
Molecular Weight90 kDa
Amino Acids854 aa
Exons11
PathwaysNF-κB
UniProt IDH0YJF5
NCBI Gene ID3320
Ensembl IDENSG00000100425
OMIM140571
GeneCardsHSP90AA1
Human Protein AtlasHSP90AA1
Associated DiseasesALS, Aging, Alzheimer, Alzheimer'S Disease
Known Drugs/CompoundsChrysotoxine, Atbc, 17-Dmag, Nvp-Auy922, Nvp-Hsp990, Bisphenol F
InteractionsHSPA1A, DNAJB1, FKBP5, P38, LC3, APP
SciDEX TargetView Target Profile (8 clinical trials)
SciDEX HypothesesHSP90-Tau Disaggregation Complex Enhancement
KG Connections731 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (17)

HDAC6 Activation as SCFA-Mediated Neuroprotective Mechanism
Score: 0.54
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.48
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.45
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.44

Related Analyses (8)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (4)

Anti-Tau Immunotherapy Dosing Optimization
clinical · proposed · Score: 0.40
Prion Strain Diversity and Selective Vulnerability
clinical · proposed · Score: 0.40
Tau PET Pattern as Therapeutic Response Predictor in 4R-Tauo
clinical · proposed · Score: 0.40
Tau Propagation Causality Test — Does Tau Spread Drive Neuro
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 3 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 3 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 3 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 3 hypotheses