protein

ANXA2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ANXA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

297Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

ANXA2 is a protein involved in neurodegeneration research. Key relationships include: activates, therapeutic target, contributes to. Associated with ALS, Als, Alzheimer. Connected to 154 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	ANXA2
Full Name	Annexin A2
Chromosome	15q22.2
Function	ANXA2 performs essential cellular functions:
Molecular Weight	~36 kDa
Amino Acids	338 aa
Exons	14
Pathways	Akt, Angiogenesis, Apoptosis, Autophagy, Blood-Brain Barrier
UniProt ID	P07355
NCBI Gene ID	303
Ensembl ID	ENSG00000146232
OMIM	151680
GeneCards	ANXA2
Human Protein Atlas	ANXA2
Protein Class	Annexin Family
Associated Diseases	Alzheimer, Alzheimer'S Disease, Cancer, Depression, Inflammation, Ms
Known Drugs/Compounds	GW201
Interactions	MTOR, PI3K, ICAM1, CD44, HMOX1, SPP1
KG Connections	297 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ANXA2 — AlphaFold P07355 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ANXA2["ANXA2"] -->|"regulates"| MTOR["MTOR"]
    ANXA2["ANXA2"] -->|"involved in"| Apoptosis["Apoptosis"]
    ANXA2["ANXA2"] -->|"modulates"| Glioblastoma_Invasion["Glioblastoma Invasion"]
    ANXA2["ANXA2"] -->|"biomarker for"| bladder_cancer["bladder cancer"]
    ANXA2["ANXA2"] -->|"therapeutic target"| Cancer["Cancer"]
    ANXA2["ANXA2"] -->|"therapeutic target"| Multiple_Sclerosis["Multiple Sclerosis"]
    ADAM8["ADAM8"] -->|"binds"| ANXA2["ANXA2"]
    ADAM8_1["ADAM8"] -->|"phosphorylates"| ANXA2["ANXA2"]
    PIN1["PIN1"] -->|"phosphorylates"| ANXA2["ANXA2"]
    ADAM8_2["ADAM8"] -->|"interacts"| ANXA2["ANXA2"]
    style ANXA2 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (232)

Target	Relation	Type	Str
Mapk Induction	mediates	process	0.90
MTOR	regulates	protein	0.85
Blood-Brain Barrier Integrity	associated_with	process	0.85
Blood-Brain Barrier Integrity	modulates	process	0.85
Glioblastoma Invasion	modulates	phenotype	0.80
Blood-Brain Barrier Integrity	regulates	process	0.80
Microplastics	binds	chemical	0.80
Apoptosis	involved_in	process	0.80
Apoptosis	modulates	process	0.80
Apoptosis	regulates	process	0.80
Tumor	regulates	disease	0.75
Cancer	regulates	disease	0.75
Breast Cancer	regulates	disease	0.75
bladder cancer	biomarker_for	disease	0.70
Cancer	therapeutic_target	disease	0.65
Multiple Sclerosis	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Depression	therapeutic_target	disease	0.65
Cardiovascular	activates	disease	0.65
Inflammation	regulates	disease	0.65
Cardiac	activates	disease	0.65
Ms	activates	disease	0.65
Fibrosis	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Depression	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Multiple Sclerosis	interacts_with	disease	0.65
Neuroinflammation	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Cardiovascular	regulates	disease	0.65
Fibrosis	regulates	disease	0.65
Als	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Inflammation	activates	disease	0.65
Stroke	activates	disease	0.65
Ischemia	activates	disease	0.65
Ms	expressed_in	disease	0.65
Neuroinflammation	contributes_to	disease	0.65
Inflammation	contributes_to	disease	0.65
Alzheimer	contributes_to	disease	0.65
Multiple Sclerosis	contributes_to	disease	0.65
Cancer	contributes_to	disease	0.65

Incoming (65)

Source	Relation	Type	Str
ADAM8	binds	protein	0.95
ADAM8	phosphorylates	protein	0.90
GW201	modulates	compound	0.85
PIN1	phosphorylates	protein	0.80
ADAM8	interacts_with	protein	0.72
CANCER	regulates	gene	0.70
ADAM8	regulates	entity	0.60
JUN	therapeutic_target	gene	0.60
ANXA1	contributes_to	gene	0.60
ADAM8	activates	gene	0.60
MTOR	activates	gene	0.60
GBM	regulates	gene	0.60
MTOR	therapeutic_target	gene	0.60
P62	activates	gene	0.60
AKT	activates	gene	0.60
LMNA	associated_with	gene	0.60
ANXA1	associated_with	gene	0.60
DYSF	associated_with	gene	0.60
JUN	contributes_to	gene	0.60
PI3K	activates	gene	0.60
ATG7	regulates	gene	0.60
ANG	activates	gene	0.60
TLR4	activates	gene	0.60
JUN	implicated_in	gene	0.60
PTK2B	interacts_with	gene	0.60
HSP90AA1	interacts_with	gene	0.60
APOPTOSIS	contributes_to	gene	0.60
ALZHEIMER'S DISEASE	contributes_to	gene	0.60
ALZHEIMER	contributes_to	gene	0.60
DEPRESSION	contributes_to	gene	0.60
CANCER	contributes_to	gene	0.60
NEUROINFLAMMATION	contributes_to	gene	0.60
INFLAMMATION	regulates	gene	0.60
AUTOPHAGY	activates	gene	0.60
GENES	regulates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
FN1	regulates	gene	0.60
MITOPHAGY	regulates	gene	0.60
LC3B	activates	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
INFLAMMATION	activates	gene	0.60
AND	activates	gene	0.60
ALZHEIMER	implicated_in	gene	0.60
CANCER	implicated_in	gene	0.60
ALZHEIMER'S DISEASE	implicated_in	gene	0.60
APOPTOSIS	activates	gene	0.60
CANCER	activates	gene	0.60
PHIP	regulates	gene	0.60
DEPRESSION	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ANXA2

Understanding Entity Pages

Summary

Wiki Pages (9)

ANXA2 — Annexin A2

DYSF — Dysferlin

Radial Glia

ANXA1 Protein — Annexin A1

ANXA2 Protein — Annexin A2

S100A10 Protein

PIN1 — Peptidyl-prolyl cis-trans Isomerase NIMA-Interacting 1