protein 1,309 words KG: IRF3PROTEIN
Contents

IRF3 Protein

🔬 Protein Info
Gene SymbolIRF3
AliasesIRF3PROTEIN
Chromosome19q13.33
Protein TypeTranscription Factor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionmost cell types, including: - Neurons and astrocytes in the brain - Microglia - Pe
Molecular Weight47 kDa
Amino Acids424 aa
Exons10
PathwaysAkt, Autophagy, Innate Immunity, Nf-Κb, Pi3K
NCBI Gene ID7099
GeneCardsIRF3
Human Protein AtlasIRF3
Associated DiseasesAD, ALI, Als, Atherosclerosis, cancer
InteractionsActin, AIM2, AKT, AKT1, ALS, ALZHEIMER
KG Connections457 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

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Related Hypotheses (15)

APOE-Dependent Autophagy Restoration
Score: 0.89
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Senescent Cell Mitochondrial DNA Release
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-Dependent Microglial Senescence Transition
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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