| Gene Symbol | ISG15 |
| Full Name | Interferon-Stimulated Gene 15 |
| Aliases | ISG15PROTEIN |
| Chromosome | 1p36.33 |
| Function | is a ubiquitin-like protein that is induced by type I interferons (IFN-α/β) and plays a critical role in the innate immune response. |
| Amino Acids | 165 aa |
| Exons | 2 |
| Pathways | Akt, Autophagy, Lipid Metabolism, Mapk, Pi3K |
| UniProt ID | [P51959](https://www.uniprot.org/uniprot/P51959) |
| Ensembl ID | ENSG00000187608 |
| OMIM | 607117 |
| GeneCards | ISG15 |
| Human Protein Atlas | ISG15 |
| Ubiquitin and ubiquitin-like proteins | SUMO, ubiquitin |
| Interferon signaling | Interferon-β, JAK-STAT pathway, NF-κB |
| Associated Diseases | Als, Alzheimer Disease, Cancer, Cognitive Deficits, Depression, Inflammation |
| Interactions | STAT1, CGAS, CXCL10, MAPT, IRF1, PINK1 |
| KG Connections | 277 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |