concept

COGNITIVE DEFICITS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COGNITIVE DEFICITS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

47Connections

0Hypotheses

1Analyses

0Outgoing

47Incoming

0Experiments

No summary available yet. View on Wiki →

💡 Concept Info

Name	COGNITIVE DEFICITS

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    COGNITIVE_DEFICITS["COGNITIVE DEFICITS"]
    microglial_repopulation["microglial repopulation"] -->|"treats"| COGNITIVE_DEFICITS
    Connexin43_Hemichannel_Blockad["Connexin43 Hemichannel Blockade"] -.protects against.-> COGNITIVE_DEFICITS
    Primary_Familial_Brain_Calcifi["Primary Familial Brain Calcification"] -->|"causes"| COGNITIVE_DEFICITS
    CHI3L1_Depletion["CHI3L1 Depletion"] -.protects against.-> COGNITIVE_DEFICITS
    Diosmin["Diosmin"] -->|"treats"| COGNITIVE_DEFICITS
    mAb2A7["mAb2A7"] -->|"treats"| COGNITIVE_DEFICITS
    Hemichannel_Blockade["Hemichannel Blockade"] -.protects against.-> COGNITIVE_DEFICITS
    CD2AP_Deficiency["CD2AP Deficiency"] -.protects against.-> COGNITIVE_DEFICITS

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (47)

Source	Relation	Type	Str
HMGB1	biomarker_for	protein	0.95
Dasatinib	treats	drug	0.92
Quercetin	treats	compound	0.92
microglial repopulation	treats	phenotype	0.90
Connexin43 Hemichannel Blockade	protects_against	mechanism	0.90
Primary Familial Brain Calcification	associated_with	disease	0.90
Primary Familial Brain Calcification	causes	disease	0.90
CHI3L1 Depletion	protects_against	mechanism	0.90
Diosmin	treats	drug	0.90
mAb2A7	treats	drug	0.90
Hemichannel Blockade	protects_against	mechanism	0.90
Tetrahydroxy Stilbene Glucoside	treats	compound	0.90
ST8SIA1	protects_against	gene	0.90
Mab2A7	treats	drug	0.90
BDNF	ameliorates	gene	0.90
GJA1	protects_against	protein	0.90
STING	contributes_to	protein	0.90
amyloid	causes	compound	0.90
Mir-532-5P	treats	biomarker	0.90
ISG15	causes	gene	0.90
Cellular Senescence	causes	process	0.88
CD2AP Deficiency	protects_against	phenotype	0.87
Amyloidosis	causes	disease	0.85
CHI3L1/CRTH2/CTNNB1 Cascade	mediates	pathway	0.85
High Glucocorticoid Levels	associated_with	biomarker	0.85
GJA1	associated_with	gene	0.85
Glucocorticoid Hormones	causes	compound	0.85
Brain Cholesterol Accumulation	causes	phenotype	0.85
Neuronal Apoptosis	causes	process	0.85
GJA1 hemichannel blockade	suppresses	process	0.85
AKT	protects_against	gene	0.85
Microglia	involved_in	cell_type	0.85
p38γ Depletion	causes	mechanism	0.82
High Glucocorticoid Levels	causes	biomarker	0.80
C9orf72 repeat expansion	causes	gene	0.80
DA1	treats	drug	0.80
reactive oxygen species	causes	compound	0.80
CONNEXIN43	prevents	protein	0.80
CONNEXIN43	mitigates	protein	0.80
Aβ plaque	causes	protein	0.70
Repetitive TBI	causes	disease	0.70
TDP-43	associated_with	protein	0.70
mitochondrial dysfunction	causes	process	0.70
inflammation	associated_with	process	0.70
CHRNA7	therapeutic_target	gene	0.60
DMPK	associated_with	gene	0.60
BDNF	protects_against	protein	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Why does prolonged anesthesia cause both cognitive dysfunction and anxiety throu

neurodegeneration | 2026-04-08 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

COGNITIVE DEFICITS

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Corticobasal Degeneration (CBD)

Frontotemporal Dementia (FTD) Mechanistic Pathway

GRIA3 Gene

Frontotemporal Dementia (FTD)

CLCN10 — Chloride Voltage-Gated Channel 10

Circadian Rhythm in Neurodegeneration

Synucleinopathy Mechanism

ncam2

APOC4 — Apolipoprotein C-IV

Wnt Non-Canonical Signaling Pathways in Neurodegeneration

amyloid-beta-metalloproteinases

cerebral-cortical-vasal-neurons

TREM2 Microglial Signaling Pathway in Neurodegeneration

CNTN6 — Contactin 6

dendritic-spines