protein 1,647 words KG: LRRK2PROTEIN
Contents

LRRK2PROTEIN Protein

🔬 Protein Info
Gene SymbolLRRK2PROTEIN
Functionis a large multi-domain protein encoded by the LRRK2 gene.
Subcellular Localization</b></td><td>Cytoplasm, membranes, mitochondria</td></tr>
Molecular Weight286 kDa
Amino Acids2527 aa
GeneCardsLRRK2PROTEIN
Human Protein AtlasLRRK2PROTEIN
Associated DiseasesALS, Aging, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/CompoundsRAPAMYCIN, levodopa, Cigarette Smoking, MLi-2, PF-06447475, Environmental Toxicants
InteractionsATG16L1, RB1CC1, GABARAP, ERN1, STAT3, IFNG
KG Connections2480 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

APOE-Dependent Autophagy Restoration
Score: 0.61
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.43
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (23)

LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Ne
validation · proposed · Score: 0.40
AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Thera
validation · proposed · Score: 0.40
AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.40
AAV Serotype Comparison for LRRK2 Knockdown in PD
validation · proposed · Score: 0.40
Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in