Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about acetylcholine: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Chemical formula | C7H16NO2+ |
| Molecular weight | 146.21 Da |
| Synthesis enzyme | Choline acetyltransferase (ChAT) |
| Degradation enzyme | Acetylcholinesterase (AChE); half-life in the synapse is approximately 1-2 milliseconds |
| Substantia innominata | Provides cholinergic[@whitehouse1982] input to the amygdala and olfactory cortex |
| Pedunculopontine nucleus (PPN) | Modulates arousal, REM sleep, locomotion; projects to thalamus and basal ganglia |
| Laterodorsal tegmental nucleus (LDT) | Involved in reward, attention, and arousal |
| Cranial nerve motor nuclei | Innervate muscles of the head and neck |
| KG Connections | 125 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
acetylcholine["<b>acetylcholine</b>"]
acetylcholinesterase["acetylcholinesterase"]
acetylcholinesterase -->|"catalyzes"| acetylcholine
TNF["TNF"]
acetylcholine -->|"inhibits"| TNF
norepinephrine["norepinephrine"]
norepinephrine -->|"activates"| acetylcholine
ALZHEIMER["ALZHEIMER"]
acetylcholine -->|"inhibits"| ALZHEIMER
Alzheimer_S_Disease["Alzheimer'S Disease"]
acetylcholine -->|"inhibits"| Alzheimer_S_Disease
disease["disease"]
acetylcholine -->|"inhibits"| disease
ALZHEIMER_S["ALZHEIMER'S"]
acetylcholine -->|"inhibits"| ALZHEIMER_S
Hippocampus["Hippocampus"]
acetylcholine -->|"activates"| Hippocampus
STROKE["STROKE"]
acetylcholine -->|"inhibits"| STROKE
apoptosis["apoptosis"]
acetylcholine -->|"inhibits"| apoptosis
Neuron["Neuron"]
acetylcholine -->|"inhibits"| Neuron
NEURONS["NEURONS"]
acetylcholine -->|"inhibits"| NEURONS
HYPOTHALAMUS["HYPOTHALAMUS"]
acetylcholine -->|"inhibits"| HYPOTHALAMUS
NUCLEUS["NUCLEUS"]
acetylcholine -->|"inhibits"| NUCLEUS
RAGE["RAGE"]
acetylcholine -->|"activates"| RAGE
HMGB1["HMGB1"]
acetylcholine -->|"activates"| HMGB1
Toll_Like_Receptor["Toll-Like Receptor"]
acetylcholine -->|"activates"| Toll_Like_Receptor
Neuron["Neuron"]
acetylcholine -->|"activates"| Neuron
NEURONS["NEURONS"]
acetylcholine -->|"activates"| NEURONS
HIF_1_["HIF-1Alpha"]
acetylcholine -->|"activates"| HIF_1_
cancer["cancer"]
acetylcholine -->|"activates"| cancer
TUMOR["TUMOR"]
acetylcholine -->|"activates"| TUMOR
Epithelial_Mesenchymal_Transition["Epithelial-Mesenchymal Transition"]
acetylcholine -->|"activates"| Epithelial_Mesenchymal_Transition
CELL_PROLIFERATION["CELL PROLIFERATION"]
acetylcholine -->|"activates"| CELL_PROLIFERATION
mTOR["mTOR"]
acetylcholine -->|"regulates"| mTOR
NF__B["NF-kappaB"]
acetylcholine -->|"regulates"| NF__B
Chemoresistance["Chemoresistance"]
acetylcholine -->|"regulates"| Chemoresistance
DOPAMINE["DOPAMINE"]
acetylcholine -->|"regulates"| DOPAMINE
SEROTONIN["SEROTONIN"]
acetylcholine -->|"regulates"| SEROTONIN
DEPRESSION["DEPRESSION"]
acetylcholine -->|"activates"| DEPRESSION| Target | Relation | Type | Str |
|---|---|---|---|
| TNF | inhibits | protein | 0.70 |
| RAGE | activates | gene | 0.50 |
| HMGB1 | activates | gene | 0.50 |
| cancer | activates | disease | 0.50 |
| VGLUT1 | inhibits | gene | 0.50 |
| ABCB1 | interacts_with | gene | 0.50 |
| CYP2D6 | interacts_with | gene | 0.50 |
| CHAT | interacts_with | gene | 0.50 |
| SLC22A1 | interacts_with | gene | 0.50 |
| CHRNA7 | interacts_with | gene | 0.50 |
| PPAR | interacts_with | protein | 0.50 |
| CYP3A4 | interacts_with | gene | 0.50 |
| CHRNA7 | expressed_in | gene | 0.50 |
| CHRNA7 | inhibits | gene | 0.50 |
| CHRNA7 | associated_with | gene | 0.50 |
| CHRNA7 | regulates | gene | 0.50 |
| NRF2 | activates | gene | 0.50 |
| FGFR1 | associated_with | gene | 0.50 |
| HCRTR1 | expressed_in | gene | 0.50 |
| CHRM4 | expressed_in | gene | 0.50 |
| ADRA2B | expressed_in | gene | 0.50 |
| GRM2 | expressed_in | gene | 0.50 |
| GRIN3B | expressed_in | gene | 0.50 |
| CHRNE | expressed_in | gene | 0.50 |
| cancer | regulates | disease | 0.50 |
| GDNF | inhibits | gene | 0.50 |
| SYN1 | associated_with | gene | 0.50 |
| ALZHEIMER | inhibits | gene | 0.50 |
| Alzheimer'S Disease | inhibits | disease | 0.50 |
| disease | inhibits | disease | 0.50 |
| ALZHEIMER'S | inhibits | concept | 0.50 |
| Hippocampus | activates | entity | 0.50 |
| STROKE | inhibits | gene | 0.50 |
| apoptosis | inhibits | process | 0.50 |
| Neuron | inhibits | cell_type | 0.50 |
| NEURONS | inhibits | concept | 0.50 |
| HYPOTHALAMUS | inhibits | concept | 0.50 |
| NUCLEUS | inhibits | concept | 0.50 |
| Toll-Like Receptor | activates | pathway | 0.50 |
| Neuron | activates | cell_type | 0.50 |
| NEURONS | activates | concept | 0.50 |
| HIF-1Α | activates | protein | 0.50 |
| TUMOR | activates | disease | 0.50 |
| Epithelial-Mesenchymal Transition | activates | process | 0.50 |
| CELL PROLIFERATION | activates | concept | 0.50 |
| mTOR | regulates | entity | 0.50 |
| NF-κB | regulates | concept | 0.50 |
| Chemoresistance | regulates | pathway | 0.50 |
| DOPAMINE | regulates | concept | 0.50 |
| SEROTONIN | regulates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| acetylcholinesterase | catalyzes | protein | 0.72 |
| norepinephrine | activates | drug | 0.70 |
| LRRK2 | activates | gene | 0.50 |
| LRRK2 | inhibits | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||