| Gene Symbol | MAOBPROTEIN |
| Full Name | B (Monoamine Oxidase B) Protein |
| Protein Type | Enzyme |
| Function | is a mitochondrial flavin adenine dinucleotide (FAD)-dependent enzyme that preferentially metabolizes phenylethylamine, benzylamine, and dopamine. |
| Primary Expression | Brain (astrocytes, substantia nigra), peripheral tissues |
| Subcellular Localization | </strong></td><td>Mitochondrial outer membrane</td></tr> |
| Molecular Weight | ~58 kDa (520 amino acids) |
| Amino Acids | 520 aa |
| UniProt ID | P27338 |
| GeneCards | MAOBPROTEIN |
| Human Protein Atlas | MAOBPROTEIN |
| FAD-binding domain (residues 1-206) | Contains the catalytic core with covalently bound FAD cofactor at position 397[@de2005] |
| C-terminal transmembrane helix | Anchors the enzyme to the mitochondrial outer membrane |
| Phenylethylamine-binding site | High affinity for phenylethylamine (Km ~ 20 µM) |
| Ile199 residue | Key determinant of B-selective inhibitors |
| Associated Diseases | Als, Alzheimer, Alzheimer's disease, Anxiety, Dementia |
| Interactions | AKT1, APP, BCL2, CASP3, GENES, GSK3B |
| KG Connections | 157 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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