protein 1,102 words KG: NR1H3PROTEIN 2026-03-30
kind:proteinsection:proteinstopic:alzheimerstopic:parkinsons
Contents

LXR-alpha Protein

🔬 Protein Info
Gene SymbolLXR
Full Namealpha Protein
AliasesLiver X Receptor
Subcellular Localization</strong></td><td>Nucleus</td></tr>
PathwaysNF-κB
GeneCardsLXR
Human Protein AtlasLXR
Associated DiseasesALS, Alzheimer, glioblastoma, neurodegeneration
Known Drugs/Compoundsrapamycin
InteractionsPS1, SOAT1, TNF, MAPK, PKA, PI3K
KG Connections103 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (14)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
APOE Isoform Conversion Therapy
Score: 0.44
APOE-Dependent Autophagy Restoration
Score: 0.61

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
GBA-Synuclein Loop Therapeutics for PD
neurodegeneration · completed

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
APOE4 (Apolipoprotein E4)
disease · Pages share 4 hypotheses
APOE3 (Apolipoprotein E3)
disease · Pages share 4 hypotheses
APOE2 (Apolipoprotein E2)
disease · Pages share 4 hypotheses
UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 4 hypotheses