protein 1,442 words KG: NRF2PROTEIN 2026-03-28
kind:proteinsection:proteinsstate:published
Contents

Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2)

🔬 Protein Info
Gene SymbolNRF2PROTEIN
Protein TypeTranscription Factor
Functionis a 605-amino acid transcription factor belonging to the CNC-bZIP family (Cap'n'Collar, alongside Nrf1, Nrf3, Bach1, Bach2).
Subcellular Localization</b></td><td>Cytoplasm (basal); nucleus (active)</td></tr>
Amino Acids605 aa
GeneCardsNRF2PROTEIN
Human Protein AtlasNRF2PROTEIN
Associated DiseasesALS, ALZHEIMER'S DISEASE, Aging, Alzheimer
Known Drugs/CompoundsRAPAMYCIN, KAEMPFEROL, GPS, EPS, VITAMINE, DMF
InteractionsGPX4, CX3CR1, TNF, CD163, CD68, ULK1
KG Connections3350 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (12)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Epigenetic Memory Reprogramming via CRISPRa-Mediated Chromat
Score: 0.52
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52

Related Analyses (11)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (14)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in