Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ATORVASTATIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | ATORVASTATIN |
| Key Genes/Proteins | NRF2, SLC16A1, SQSTM1, P2RY12, ABCA1, AMPK |
| Related Diseases | CHOLESTEROL, AUTOPHAGY, ALS |
Knowledge base pages for this entity
graph TD
ATORVASTATIN["ATORVASTATIN"]
ATORVASTATIN -->|"treats"| Acute_Kidney_Injury["Acute Kidney Injury"]
ATORVASTATIN ---|"associated"| CHLOROQUINE["CHLOROQUINE"]
ATORVASTATIN ---|"associated"| CHOLESTEROL["CHOLESTEROL"]
ATORVASTATIN ---|"associated"| AUTOPHAGY["AUTOPHAGY"]
ATORVASTATIN ---|"associated"| SQSTM1["SQSTM1"]
ATORVASTATIN ---|"associated"| P2RY12["P2RY12"]
SLC16A1["SLC16A1"] -->|"interacts"| ATORVASTATIN
ATHEROSCLEROSIS["ATHEROSCLEROSIS"] ---|"associated"| ATORVASTATIN
ENDOTHELIAL_CELLS["ENDOTHELIAL CELLS"] ---|"associated"| ATORVASTATIN
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] ---|"associated"| ATORVASTATIN| Target | Relation | Type | Str |
|---|---|---|---|
| NRF2 | activates | gene | 0.70 |
| NRF2 | treats | gene | 0.70 |
| NRF2 | associated_with | gene | 0.50 |
| CHLOROQUINE | associated_with | drug | 0.45 |
| CHOLESTEROL | associated_with | phenotype | 0.45 |
| AUTOPHAGY | associated_with | phenotype | 0.45 |
| SQSTM1 | associated_with | gene | 0.45 |
| P2RY12 | associated_with | gene | 0.45 |
| ABCA1 | associated_with | gene | 0.45 |
| AMPK | associated_with | gene | 0.45 |
| ATG5 | associated_with | gene | 0.45 |
| ULK1 | associated_with | gene | 0.45 |
| ALS | associated_with | disease | 0.45 |
| ALZHEIMER | associated_with | disease | 0.45 |
| AMYLOID | associated_with | protein | 0.45 |
| ATP | associated_with | phenotype | 0.45 |
| ENDOTHELIAL CELLS | associated_with | cell_type | 0.45 |
| ABCG1 | associated_with | gene | 0.45 |
| HMGCR | associated_with | gene | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| LIRAGLUTIDE | inhibits | drug | 0.70 |
| SLC16A1 | interacts_with | gene | 0.60 |
| ATHEROSCLEROSIS | associated_with | disease | 0.45 |
| ENDOTHELIAL CELLS | associated_with | cell_type | 0.45 |
| ALZHEIMER'S DISEASE | associated_with | disease | 0.45 |
| ABCA1 | associated_with | gene | 0.45 |
| ALS | associated_with | disease | 0.45 |
| AMPK | associated_with | gene | 0.45 |
| ATG5 | associated_with | gene | 0.45 |
| ALZHEIMER | associated_with | disease | 0.45 |
| AMYLOID | associated_with | protein | 0.45 |
| AUTOPHAGOSOMES | associated_with | organelle | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||