protein 619 words KG: P2X7PROTEIN 2026-03-20
kind:proteinsection:proteinsstate:published
Contents

P2X7 Protein

🔬 Protein Info
Gene SymbolP2X7
Full NameP2X Purinoceptor 7
AliasesP2X7PROTEIN
Chromosome12q24.31.
Protein TypeChannel
FunctionIn the healthy brain, P2X7 serves several important physiological roles:
Molecular Weight68.5 kDa
Amino Acids595 aa
Exons17
PathwaysAmyloid, Apoptosis, Er Stress, Inflammasome, Microrna
Ensembl IDENSG00000088038
GeneCardsP2X7
Human Protein AtlasP2X7
Associated DiseasesALS, Alzheimer, Alzheimer'S Disease, Autoimmune, Cancer
InteractionsP2RX7, P2RX4, SRC, CX3CR1, AKT, VDAC1
KG Connections384 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (8)

Purinergic Signaling Polarization Control
Score: 0.55
Temporal Decoupling via Circadian Clock Reset
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Microglial Purinergic Reprogramming
Score: 0.48
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.48

Related Analyses (7)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (4)

P2rx7 congenic mouse model insulin tolerance testing
validation · proposed · Score: 0.90
P2rx7 congenic mouse model glucose tolerance testing
validation · proposed · Score: 0.90
Gap Junction Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Purinergic Signaling Dysfunction Validation in Parkinson's D
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in