Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about adnp: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ADNP |
| Protein Type | Transcription Factor |
| Function | ADNP encodes a 1,102 amino acid protein containing a homeobox domain, nine zinc fingers, and a PxVxL motif that mediates interaction with the SWI/SNF chromatin remodeling complex through HP1. |
| Molecular Weight | 124 kDa |
| Amino Acids | 102 aa |
| Pathways | Autophagy, Epigenetic, Wnt |
| Ensembl ID | ENSG00000101126 |
| GeneCards | ADNP |
| Human Protein Atlas | ADNP |
| Associated Diseases | Ms, Aging |
| Interactions | ALZHEIMER, P2X7 RECEPTOR, P2X7 |
| KG Connections | 21 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["adnp"]
N1["SYNAPSE"]
N0 -->|"regulates"| N1
N2["Neuroprotection"]
N0 -->|"regulates"| N2
N0 -->|"expressed in"| N1
N3["GENE EXPRESSION"]
N0 -->|"expressed in"| N3
N4["ALZHEIMER"]
N0 -->|"activates"| N4
N5["Alzheimer'S Disease"]
N0 -->|"activates"| N5
N6["disease"]
N0 -->|"activates"| N6
N7["ALZHEIMER'S"]
N0 -->|"activates"| N7
N8["Astrocytes"]
N0 -->|"inhibits"| N8
N9["Astrocyte"]
N0 -->|"inhibits"| N9
N10["APP/PS1"]
N0 -->|"inhibits"| N10
N0 -->|"expressed in"| N8
N0 -->|"expressed in"| N9
N11["P2X7 RECEPTOR"]
N0 -->|"inhibits"| N11
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N4 gene
class N5 disease
class N6 disease
class N11 protein| Target | Relation | Type | Str |
|---|---|---|---|
| SYNAPSE | regulates | concept | 0.50 |
| Neuroprotection | regulates | process | 0.50 |
| SYNAPSE | expressed_in | concept | 0.50 |
| GENE EXPRESSION | expressed_in | concept | 0.50 |
| ALZHEIMER | activates | gene | 0.50 |
| Alzheimer'S Disease | activates | disease | 0.50 |
| disease | activates | disease | 0.50 |
| ALZHEIMER'S | activates | concept | 0.50 |
| Astrocytes | inhibits | cell_type | 0.50 |
| Astrocyte | inhibits | cell_type | 0.50 |
| APP/PS1 | inhibits | concept | 0.50 |
| Astrocytes | expressed_in | cell_type | 0.50 |
| Astrocyte | expressed_in | cell_type | 0.50 |
| P2X7 RECEPTOR | inhibits | protein | 0.50 |
| P2X7 | inhibits | protein | 0.50 |
| Neuron | inhibits | cell_type | 0.50 |
| NEURONS | inhibits | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AUTISM | regulates | disease | 0.50 |
| AUTISM | protects_against | disease | 0.50 |
| SCHIZOPHRENIA | activates | disease | 0.50 |
| AUTISM | inhibits | disease | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||