protein 973 words KG: PIK3CAPROTEIN 2026-03-23
kind:proteinsection:proteinsstate:published
Contents

PI3K p110α Protein

🔬 Protein Info
Gene SymbolPIK3CA
AliasesPIK3CAPROTEIN
Chromosome3q26.32
FunctionMechanism
Molecular Weight120 kDa
Amino Acids068 aa
Exons21
PathwaysPI3K, mTOR
GeneCardsPIK3CA
Human Protein AtlasPIK3CA
Synaptic plasticityCREB activation, AMPA receptor trafficking
Neuronal survivalAkt-mediated BAD inactivation
Growth cone guidancecytoskeletal reorganization
MetabolismGlucose uptake regulation
[Autophagy](/entities/autophagy)mTORC1 inhibition
Associated DiseasesALS, Aging, BREAST CANCER
Known Drugs/CompoundsChrysotoxine, Apitolisib, Paxalisib, Alpelisib, rapamycin
InteractionsPTEN, AKT, PI3K, MMP9, PPARA, IGF1R
KG Connections779 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

TREM2-DAP12 Signalosome Enhancement — Boosting PI3K-AKT-mTOR
Score: 0.45
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
APOE-Dependent Autophagy Restoration
Score: 0.61
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (7)

Can biased TREM2 agonists selectively activate DAP12-SYK-PI3
molecular biology · failed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (9)

Network pharmacology analysis of QTJD active compounds and p
exploratory · proposed · Score: 0.90
S-equol-induced ferroptosis mechanism in TNBC cells
exploratory · proposed · Score: 0.90
VSMC cholesterol efflux and P2RY12 signaling
exploratory · proposed · Score: 0.90
P2RY12-MTOR pathway interaction in VSMCs
exploratory · proposed · Score: 0.85
In vivo autophagy modulation in atherosclerotic mice
validation · proposed · Score: 0.85

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in