Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about acvr1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ACVR1 |
| Aliases | Activin A Receptor Type 1 (ALK2) |
| Chromosome | 2q24.1 |
| Protein Type | Serine/Threonine Kinase |
| Function | is a transmembrane serine/threonine kinase receptor that plays critical roles in development, tissue homeostasis, and disease pathogenesis. |
| Molecular Weight | 56 kDa |
| Amino Acids | 509 aa |
| Exons | 11 |
| Pathways | inflammation |
| GeneCards | ACVR1 |
| Human Protein Atlas | ACVR1 |
| Associated Diseases | Fibrodysplasia Ossificans Progressiva, neurodegeneration |
| Interactions | SMAD |
| KG Connections | 6 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ACVR1["ACVR1"]
ACVR1 -->|"causes"| Fibrodysplasia_Ossificans_Prog["Fibrodysplasia Ossificans Progressiva"]
ACVR1 -->|"activates"| NF__B["NF-kappaB"]
ACVR1 -->|"interacts"| Aging["Aging"]
ACVR1 -->|"interacts"| Als["Als"]
ACVR1 -->|"interacts"| Cancer["Cancer"]
ACVR1 -->|"interacts"| Lymphoma["Lymphoma"]
ACVR1 -->|"interacts"| Tumor["Tumor"]
ACVR1 -->|"activates"| Inflammation["Inflammation"]
PIK3CA["PIK3CA"] -->|"interacts"| ACVR1
RANKINGS["RANKINGS"] -->|"interacts"| ACVR1
RAC1["RAC1"] -->|"interacts"| ACVR1
MAPK1["MAPK1"] -->|"interacts"| ACVR1
PI3K["PI3K"] -->|"interacts"| ACVR1
CBL["CBL"] -->|"interacts"| ACVR1
AKT["AKT"] -->|"interacts"| ACVR1
RHOA["RHOA"] -->|"interacts"| ACVR1| Target | Relation | Type | Str |
|---|---|---|---|
| mTOR | activates | entity | 0.50 |
| SMAD | activates | protein | 0.50 |
| inflammation | activates | pathway | 0.50 |
| NF-κB | activates | concept | 0.50 |
| MACROPHAGES | activates | concept | 0.50 |
| STEM CELLS | activates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PIK3CA | interacts_with | gene | 0.60 |
| RANKINGS | interacts_with | gene | 0.60 |
| RAC1 | interacts_with | gene | 0.60 |
| MAPK1 | interacts_with | gene | 0.60 |
| PI3K | interacts_with | gene | 0.60 |
| CBL | interacts_with | gene | 0.60 |
| AKT | interacts_with | gene | 0.60 |
| RHOA | interacts_with | gene | 0.60 |
| TRAF2 | interacts_with | gene | 0.60 |
| TRAF6 | interacts_with | gene | 0.60 |
| TGFBR1 | interacts_with | gene | 0.60 |
| PTEN | interacts_with | gene | 0.60 |
| RAF1 | interacts_with | gene | 0.60 |
| CDC42 | interacts_with | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| NLRP3 | activates | gene | 0.60 |
| benchmark_ot_ad_answer_key:ACVR1 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||