Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about arhgef7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ARHGEF7 |
| Full Name | Rho Guanine Nucleotide Exchange Factor 7 |
| Chromosome | 13q14.3 |
| Function | This domain adopts a Dbl-like fold that facilitates the conformational changes required for GDP release and GTP binding. |
| Primary Expression | the brain, particularly in the cerebral cortex and hippocampus, where it localizes to [dendriti |
| Amino Acids | 803 aa |
| Ensembl ID | ENSG00000150760 |
| GeneCards | ARHGEF7 |
| Human Protein Atlas | ARHGEF7 |
| Associated Diseases | Als, ALS, neurodegeneration |
| Interactions | LRRK2 |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ARHGEF7["ARHGEF7"]
ARHGEF7 -->|"regulates"| Dendritic_Spine_Morphogenesis["Dendritic Spine Morphogenesis"]
ARHGEF7 -->|"activates"| RAC1["RAC1"]
ARHGEF7 -->|"regulates"| Ms["Ms"]
ARHGEF7 -->|"interacts"| Parkinson["Parkinson"]
ARHGEF7 -->|"regulates"| Als["Als"]
ARHGEF7 -->|"regulates"| ALS["ALS"]
SRC["SRC"] -->|"phosphorylates"| ARHGEF7
Glutamate["Glutamate"] -->|"activates"| ARHGEF7
AMPA_RECEPTOR["AMPA RECEPTOR"] -->|"modulates"| ARHGEF7
NMDA_RECEPTOR["NMDA RECEPTOR"] -->|"modulates"| ARHGEF7
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"interacts"| ARHGEF7
RAB7L1["RAB7L1"] -->|"interacts"| ARHGEF7
SYNAPSE["SYNAPSE"] -->|"regulates"| ARHGEF7| Target | Relation | Type | Str |
|---|---|---|---|
| NEURONS | interacts_with | concept | 0.50 |
| Neuroblastoma | inhibits | disease | 0.50 |
| Neuron | activates | cell_type | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||