protein 842 words KG: SYNAPTOPHYSINPROTEIN
Contents

Synaptophysin Protein

🔬 Protein Info
Gene SymbolSYP
Full NameSynaptophysin
AliasesSYNAPTOPHYSINPROTEIN
ChromosomeXp11.23
FunctionSynaptophysin is the most abundant synaptic vesicle membrane protein, constituting up to 10% of all synaptic vesicle proteins.
Primary ExpressionBrain (cortex, hippocampus), cerebellum, retina, neuroendocrine cells
Molecular Weight38 kDa
Amino Acids316 aa
PathwaysAmyloid, Apoptosis
UniProt IDP21579
Ensembl IDENSG00000100391
GeneCardsSYP
Human Protein AtlasSYP
Length313 amino acids
Molecular weightApproximately 38 kDa
Associated DiseasesALS, Epilepsy, Ms
InteractionsAKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, ANXIETY, APP
KG Connections309 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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UniProtWikipedia

Related Hypotheses (46)

SASP-Mediated Complement Cascade Amplification
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Transcriptional Autophagy-Lysosome Coupling
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Phase-Separated Organelle Targeting
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72
Stress Granule Phase Separation Modulators
Score: 0.72
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
Purinergic Signaling Polarization Control
Score: 0.71
Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.71
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71
Orexin-Microglia Modulation Therapy
Score: 0.71
Lysosomal Enzyme Trafficking Correction
Score: 0.71
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
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Related Analyses (22)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (4)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40
DLB Cognitive Fluctuation Mechanism Experiment
clinical · proposed · Score: 0.40

See Also (15)

DALY Methodology — Neurodegeneration
disease · Pages share 41 hypotheses
China Neurodegeneration Epidemiology
disease · Pages share 41 hypotheses
Cell-Free DNA Biomarkers in Neurodegeneration
biomarker · Pages share 41 hypotheses
Olfactory Mucosa, Blood and Urine for Identification of
clinical · Pages share 41 hypotheses
Swedish BioFINDER 2 Study: Biomarkers and Neurodegenera
clinical · Pages share 41 hypotheses

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