protein 842 words KG: SYNAPTOPHYSINPROTEIN 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

Synaptophysin Protein

🔬 Protein Info
Gene SymbolSYP
Full NameSynaptophysin
AliasesSYNAPTOPHYSINPROTEIN
ChromosomeXp11.23
FunctionSynaptophysin is the most abundant synaptic vesicle membrane protein, constituting up to 10% of all synaptic vesicle proteins.
Primary ExpressionBrain (cortex, hippocampus), cerebellum, retina, neuroendocrine cells
Molecular Weight38 kDa
Amino Acids316 aa
PathwaysAmyloid, Apoptosis
UniProt IDP21579
Ensembl IDENSG00000100391
GeneCardsSYP
Human Protein AtlasSYP
Length313 amino acids
Molecular weightApproximately 38 kDa
Associated DiseasesALS, Epilepsy, Ms
InteractionsIL6, BDNF, GFAP, RAB5, GDI1, RAB3A
KG Connections315 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Senescence-Activated NAD+ Depletion Rescue
Score: 0.60
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59

Related Analyses (22)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived

Related Experiments (4)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40
DLB Cognitive Fluctuation Mechanism Experiment
clinical · proposed · Score: 0.40

See Also (15)

Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 41 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 41 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 41 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 41 hypotheses
Vagus Nerve Pathway in Neurodegeneration
mechanism · Pages share 41 hypotheses