| Gene Symbol | TIGAR |
| Full Name | TP53 induced glycolysis and apoptosis regulator |
| Aliases | TIGARPROTEIN |
| Chromosome | 12p13.1 |
| Protein Type | Enzyme |
| Function | is a gene encoding a bifunctional enzyme with fructose-2,6-bisphosphatase activity. |
| Subcellular Localization | 3. **p53 Binding Sites**: The TIGAR promoter contains p53 response elements, allowing direct transcriptional activation |
| Exons | 6 |
| Pathways | Apoptosis, Autophagy, Chaperone, Glycolysis, Mitophagy |
| UniProt ID | [Q9Y2H7](https://www.uniprot.org/uniprot/Q9Y2H7) |
| Ensembl ID | ENSG00000148231 |
| OMIM | 610335 |
| GeneCards | TIGAR |
| Human Protein Atlas | TIGAR |
| [p53](/proteins/p53-protein) | Transcriptional regulation |
| Associated Diseases | AD, ALS, AMI, ARM, Ms |
| Interactions | GAIN, TAK1, ATR, Hif-1, Sumo, CANCER |
| KG Connections | 111 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |