| Gene Symbol | TP53 |
| Full Name | Tumor Protein P53 |
| Aliases | TP53PROTEIN |
| Chromosome | 17p13.1 |
| Function | p53 regulates cell cycle arrest, DNA repair, and apoptosis in response to cellular stress. |
| Primary Expression | all neuronal populations including:
- Cortical neurons (layer 2-6)
- Hippocampal neurons (CA1-CA3, dentate gyrus granule cells)
- Dopaminergic neurons |
| Subcellular Localization | </strong></td><td>Nucleus, cytoplasm</td></tr> |
| Amino Acids | 393 aa |
| Exons | 11 |
| Pathways | Akt, Apoptosis, Autophagy, Blood-Brain Barrier, Cell Cycle |
| UniProt ID | [P04637](https://www.uniprot.org/uniprot/P04637) |
| Ensembl ID | ENSG00000141510 |
| GeneCards | TP53 |
| Human Protein Atlas | TP53 |
| N-terminal transactivation domain (TAD) | Residues 1-61, binds transcriptional coactivators |
| Associated Diseases | AD, ALI, ALS, Aging, Alzheimer |
| Known Drugs/Compounds | RAPAMYCIN, Mifepristone, Tinospora cordifolia, Emodin, CHRYSOTIXINE, rapamycin |
| Interactions | EFNB1, EPHB4, SRC, DNMT3A, U2AF1, TERT |
| KG Connections | 2425 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |