gene

ACVR2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACVR2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

66Connections

0Hypotheses

0Analyses

49Outgoing

17Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	ACVR2A
Full Name	Activin A Receptor Type 2A
Chromosome	2q22.3
Protein Type	Serine/Threonine Kinase
Function	is a member of the TGF-beta superfamily of serine/threonine kinase receptors.
Amino Acids	513 aa
Pathways	Apoptosis, Dna Repair, Epigenetic
UniProt ID	[P27037](https://www.uniprot.org/uniprot/P27037)
Ensembl ID	ENSG00000198893
GeneCards	ACVR2A
Human Protein Atlas	ACVR2A
Inhibins	Can form complexes with ACVR2A to modulate signaling
BMPs	Bone morphogenetic proteins can also activate ACVR2A at higher concentrations
Phosphorylation	Multiple serine/threonine residues in the kinase domain are phosphorylated during activation
Glycosylation	N-linked glycosylation in the extracellular domain affects ligand binding
Associated Diseases	Als, Cancer, Colorectal Cancer, Gastric Cancer, HCC, Hepatocellular Carcinoma
Interactions	CTNNB1, TP53, TERT, GENES, CANCER, OXIDATIVE STRESS
KG Connections	66 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ACVR2A["ACVR2A"] -->|"associated"| Hepatocellular_Carcinoma["Hepatocellular Carcinoma"]
    style Hepatocellular_Carcinoma fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ACVR2A["ACVR2A"] -.->|"inhibits"| Cell_Proliferation["Cell Proliferation"]
    style Cell_Proliferation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    ACVR2A["ACVR2A"] -->|"activates"| Cancer["Cancer"]
    style Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ACVR2A["ACVR2A"] -->|"activates"| Carcinoma["Carcinoma"]
    style Carcinoma fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ACVR2A["ACVR2A"] -->|"activates"| Hepatitis["Hepatitis"]
    style Hepatitis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ACVR2A["ACVR2A"] -->|"activates"| Inflammation["Inflammation"]
    style Inflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ACVR2A["ACVR2A"] -->|"associated"| Colorectal_Cancer["Colorectal Cancer"]
    style Colorectal_Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    TP53["TP53"] -->|"activates"| ACVR2A["ACVR2A"]
    style TP53 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    TERT["TERT"] -->|"activates"| ACVR2A["ACVR2A"]
    style TERT fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"activates"| ACVR2A["ACVR2A"]
    style OXIDATIVE_STRESS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    GENES["GENES"] -->|"activates"| ACVR2A["ACVR2A"]
    style GENES fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    INFLAMMATION["INFLAMMATION"] -->|"activates"| ACVR2A["ACVR2A"]
    style INFLAMMATION fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style ACVR2A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (49)

Target	Relation	Type	Str
Hepatocellular Carcinoma	associated_with	disease	0.90
Hepatocellular Carcinoma	biomarker_for	disease	0.88
Cell Proliferation	inhibits	process	0.85
Cell Proliferation	regulates	process	0.85
Cancer	activates	disease	0.65
Carcinoma	activates	disease	0.65
Hepatitis	activates	disease	0.65
Inflammation	activates	disease	0.65
Colorectal Cancer	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Gastric Cancer	associated_with	disease	0.65
Hepatocellular Carcinoma	activates	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Cancer	regulates	disease	0.65
HCC	associated_with	disease	0.64
CTNNB1	activates	gene	0.60
TP53	activates	gene	0.60
TERT	activates	gene	0.60
MRE11	associated_with	gene	0.60
MSH2	associated_with	gene	0.60
MSH3	regulates	gene	0.60
MLH1	associated_with	gene	0.60
MSH6	regulates	gene	0.60
HDAC2	regulates	gene	0.60
PMS2	associated_with	gene	0.60
AKT	associated_with	gene	0.60
Oxidative Stress	activates	pathway	0.60
Wnt	activates	pathway	0.60
Tgf-Β	activates	pathway	0.60
GENES	activates	gene	0.60
CANCER	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
CANCER	associated_with	gene	0.60
GENES	associated_with	gene	0.60
DNA	regulates	gene	0.60
Dna Repair	regulates	pathway	0.60
Apoptosis	regulates	pathway	0.60
Microrna	associated_with	pathway	0.60
Mismatch Repair	associated_with	pathway	0.60
Epigenetic	regulates	pathway	0.60
INFLAMMATION	activates	gene	0.60
CANCER	regulates	gene	0.60
Akt	associated_with	pathway	0.60
Pi3K	activates	pathway	0.60
RNA	activates	gene	0.60
AND	activates	gene	0.60
P53	activates	protein	0.60
CELL PROLIFERATION	activates	concept	0.50

Incoming (17)

Source	Relation	Type	Str
TP53	activates	gene	0.60
TERT	activates	gene	0.60
CTNNB1	activates	gene	0.60
BAX	regulates	gene	0.60
BRAF	associated_with	gene	0.60
TGFBR2	regulates	gene	0.60
ARID1A	regulates	gene	0.60
PI3K	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
GENES	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
CANCER	activates	gene	0.60
APOPTOSIS	regulates	gene	0.60
AND	regulates	gene	0.60
WNT	activates	gene	0.60
RNA	activates	gene	0.60
AND	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ACVR2A

Understanding Entity Pages

Wiki Pages (11)

ACVR2A Gene

SMAD5 — SMAD Family Member 5

BMPR1A — Bone Morphogenetic Protein Receptor Type 1A

ACVR1 Gene

SMAD5 Protein

Activin A Receptor Type 1B (ACVR1B)

TGF-β/BMP Signaling Pathway in Neurodegeneration

BMPR1A (ALK3) Protein

GDF Signaling Pathway in Neurodegeneration