gene 1,417 words KG: SIRT2
Contents

SIRT2 Gene

🧬 Gene Info
Gene SymbolSIRT2
Full NameSirtuin 2
Chromosome19q13.32
FunctionThis function is critical for
Primary Expressionboth cytoplasmic and nuclear compartments
Subcellular Localization**Primary**: Cytoplasm, where it deacetylates alpha-tubulin
Molecular Weight43 kDa
Amino Acids389 aa
Exons13 coding exons
PathwaysAutophagy, Necroptosis, Oxidative Stress
UniProt IDQ8IXJ6
NCBI Gene ID22933
Ensembl IDENSG00000145335
OMIM604479
GeneCardsSIRT2
Human Protein AtlasSIRT2
Associated Diseasesaging, ALS, Alzheimer, alzheimers, Alzheimer's disease
Known Drugs/CompoundsMMP9_IN1
InteractionsAGING, AIM2, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID
KG Connections282 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Knowledge Graph (12 edges)

MMP9_IN1 activates SIRT2
SIRT2 activates NRF2
MMP9 regulates SIRT2
SIRT2 regulates NRF2
SIRT2 regulates MMP9
SIRT6 associated_with SIRT2
HDAC11 regulates SIRT2
HDAC2 regulates SIRT2
SIRT7 expressed_in SIRT2
SIRT5 expressed_in SIRT2

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