| Gene Symbol | SIRT7 |
| Full Name | Sirtuin 7 (Nuclear NAD-dependent deacetylase) |
| Aliases | SIRT7 sirtuin |
| Chromosome | 17q25.3 |
| Function | is a NAD+-dependent nuclear class III deacetylase predominantly localized to nucleoli where it regulates ribosomal RNA transcription and ribosome biogenesis. |
| Primary Expression | High in brain (cortex, hippocampus, substantia nigra), heart, liver |
| Subcellular Localization | nucleoli where it regulates ribosomal RNA transcription and ribosome biogenesis. It is the least characterized mammalian |
| Molecular Weight | 44 kDa |
| Amino Acids | 400 aa |
| Pathways | Apoptosis, Autophagy, Mtor, Oxidative Stress |
| UniProt ID | Q9H0U6 |
| NCBI Gene ID | 23433 |
| Ensembl ID | ENSG00000117595 |
| OMIM | 613213 |
| GeneCards | SIRT7 |
| Human Protein Atlas | SIRT7 |
| Associated Diseases | Aging, Cancer, Neurodegeneration |
| Interactions | AMPK, ATP, CDK2, DDX3X, ERK1/2, FBXO7 |
| KG Connections | 136 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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