gene

CDK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CDK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

245Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

CDK2 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, expressed in. Associated with ALS, Aging, Als. Connected to 120 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CDK2
Full Name	Cyclin-Dependent Kinase 2
Aliases	CDK2, p33
Chromosome	12q13.2
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	34 kDa
Amino Acids	297 aa
Exons	9
Pathways	Cell Cycle, Cell Division
UniProt ID	P24941
NCBI Gene ID	1017
Ensembl ID	ENSG00000145386
GeneCards	CDK2
Human Protein Atlas	CDK2
Drug	Primary Target
Associated Diseases	ALS, Aging, Cancer, Gastric Cancer, Ms, Neurodegeneration
Known Drugs/Compounds	Thiabendazole
Interactions	APC, JUN, PTK2, MYC, UBIQUITIN, EGFR
KG Connections	245 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CDK2 — AlphaFold P24941 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CDK2["CDK2"]
    CDK2 -->|"activates"| Cancer["Cancer"]
    CDK2 -->|"activates"| Ms["Ms"]
    CDK2 -->|"activates"| Als["Als"]
    CDK2 -->|"target for"| Carcinoma["Carcinoma"]
    CDK2 -->|"expressed in"| Glioblastoma["Glioblastoma"]
    JUN["JUN"] -->|"inhibits"| CDK2
    CDH1["CDH1"] -->|"activates"| CDK2
    DNA["DNA"] -->|"activates"| CDK2
    APC["APC"] -->|"activates"| CDK2
    BAX["BAX"] -->|"expressed in"| CDK2
    CDK1["CDK1"] -->|"activates"| CDK2
    EGFR["EGFR"] -->|"expressed in"| CDK2
    BCL_2["BCL-2"] -->|"expressed in"| CDK2
    APOPTOSIS["APOPTOSIS"] -->|"expressed in"| CDK2

Outgoing (160)

Target	Relation	Type	Str
TRIM32	phosphorylates	protein	0.95
Cell Cycle Entry	activates	process	0.90
radioresistance	promotes	phenotype	0.88
E2F Transcription Program	activates	pathway	0.85
Oncogene-Induced Senescence	involved_in	process	0.85
Microvascular Anomalies	mediates	phenotype	0.85
gastric cancer	promotes	disease	0.82
prostate cancer	promotes	disease	0.82
Liver Injury	involved_in	disease	0.80
Microvascular Anomalies	involved_in	phenotype	0.80
cell cycle entry	promotes	process	0.80
Gastric Cancer	associated_with	disease	0.80
Gastric Cancer	involved_in	disease	0.80
EGFR	coexpressed_with	gene	0.75
telomere shortening	regulates	process	0.75
Als	activates	disease	0.75
Cancer	therapeutic_target	disease	0.75
Tumor	regulates	disease	0.75
Cell Cycle	activates	pathway	0.70
Cancer	activates	disease	0.65
Ms	activates	disease	0.65
Als	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Ms	expressed_in	disease	0.65
Glioblastoma	expressed_in	disease	0.65
Aging	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
Cancer	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Aging	activates	disease	0.65
ALS	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	interacts_with	disease	0.65
Als	treats	disease	0.65
Inflammation	treats	disease	0.65
Infection	regulates	disease	0.65
Als	regulates	disease	0.65
Viral Infection	regulates	disease	0.65
Obesity	causes	disease	0.65
ALS	inhibits	disease	0.65
Retinopathy	therapeutic_target	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Aging	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
APC	activates	gene	0.60
JUN	inhibits	gene	0.60

Incoming (85)

Source	Relation	Type	Str
FTO	targets	protein	0.95
JUN	inhibits	gene	0.90
XHP	downregulates	drug	0.90
Thiabendazole	binds	drug	0.90
Thiabendazole	binds_to	drug	0.88
APC/C(CDH1)	regulates	enzyme	0.85
Lactylation	regulates	process	0.75
JUN	activates	gene	0.60
APC	activates	gene	0.60
FYN	associated_with	gene	0.60
MAPK3	associated_with	gene	0.60
PAK1	associated_with	gene	0.60
BAX	expressed_in	gene	0.60
CDK1	activates	gene	0.60
EGFR	expressed_in	gene	0.60
H2AX	expressed_in	gene	0.60
GBM	expressed_in	gene	0.60
SIRT6	associated_with	gene	0.60
MTOR	interacts_with	gene	0.60
SIRT7	associated_with	gene	0.60
RANK	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60
MAPK8	associated_with	gene	0.60
FOXO3	associated_with	gene	0.60
SIRT1	associated_with	gene	0.60
SOX2	interacts_with	gene	0.60
ATF2	activates	gene	0.60
CSF1	activates	gene	0.60
BNIP3L	activates	gene	0.60
NEAT1	interacts_with	gene	0.60
PPARG	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
CDK6	therapeutic_target	gene	0.60
EGFR	therapeutic_target	gene	0.60
CHEK1	interacts_with	gene	0.60
CDK1	interacts_with	gene	0.60
DNAJB6	inhibits	gene	0.60
CDK4	inhibits	gene	0.60
JNK	inhibits	gene	0.60
HDAC4	inhibits	gene	0.60
EGFR	activates	gene	0.60
HTT	inhibits	gene	0.60
HUNTINGTIN	inhibits	gene	0.60
APC	inhibits	gene	0.60
AKT	activates	gene	0.60
CDH1	activates	gene	0.60
DNA	activates	gene	0.60
BCL-2	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
AGING	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CDK2

Understanding Entity Pages

Summary

Wiki Pages (21)

CDK2 Gene

FOXO1 Protein

Cellular Senescence in Neurodegeneration

FOXO4 — Forkhead Box O4

Litronesib (LY317615/Enzastaurin)

Centrosome

Cyclin E2 (CCNE2) Protein

Cellular Senescence in Brain Aging and Neurodegeneration

Anti-Tau Therapeutics

WEE1 Protein (WEE1 Kinase)

E2F4 Gene

CDK5 Protein

mRNA Therapeutics for Neurodegenerative Diseases

stathmin

Cell Cycle Dysregulation in 4R-Tauopathies

DYRK1B Protein

Protein Kinase Inhibitors for Neurodegeneration: Investment Landscape Analysis

CDKN1B — Cyclin-Dependent Kinase Inhibitor 1B

E2F5 Gene