DDX3X

Understanding Entity Pages

This page aggregates everything SciDEX knows about DDX3X: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

DDX3X is a gene implicated in neurodegeneration research. Key relationships include: expressed in, inhibits, activates. Associated with Als, Amyotrophic Lateral Sclerosis, Dementia. Connected to 30 entities in the SciDEX knowledge graph.

View on Wiki →

graph TD
    DDX3X["<b>DDX3X</b>"]
    Inflammation{"Inflammation"}
    DDX3X -->|"activates"| Inflammation
    Als{"Als"}
    DDX3X -->|"inhibits"| Als
    Neuroinflammation{"Neuroinflammation"}
    DDX3X -->|"activates"| Neuroinflammation
    Ms{"Ms"}
    DDX3X -->|"inhibits"| Ms
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    DDX3X -->|"inhibits"| Amyotrophic_Lateral_Sclerosis
    Dementia{"Dementia"}
    DDX3X -->|"inhibits"| Dementia
    Lymphoma{"Lymphoma"}
    DDX3X -->|"expressed in"| Lymphoma
    DDX3X -->|"expressed in"| Als
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    DDX3X -->|"inhibits"| AMYOTROPHIC_LATERAL_SCLEROSIS
    NEUROTOXICITY["NEUROTOXICITY"]
    DDX3X -->|"activates"| NEUROTOXICITY
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    DDX3X -->|"activates"| NEUROINFLAMMATION
    C9ORF72["C9ORF72"]
    DDX3X -->|"inhibits"| C9ORF72
    P62["P62"]
    P62 -->|"inhibits"| DDX3X
    RAN["RAN"]
    RAN -->|"regulates"| DDX3X
    CDKN2A["CDKN2A"]
    CDKN2A -->|"expressed in"| DDX3X
    TP53["TP53"]
    TP53 -->|"expressed in"| DDX3X
    TET2["TET2"]
    TET2 -->|"expressed in"| DDX3X
    MYD88["MYD88"]
    MYD88 -->|"expressed in"| DDX3X
    KMT2D["KMT2D"]
    KMT2D -->|"expressed in"| DDX3X
    NF__B["NF-KappaB"]
    NF__B -->|"expressed in"| DDX3X
    STAT3["STAT3"]
    STAT3 -->|"expressed in"| DDX3X
    style DDX3X fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0