therapeutic 1,461 words KG: ent-gene-f3a46d3d
Contents

CD47-SIRPα Immune Checkpoint Therapy

🔬 Protein Info
Gene SymbolCD47
Full NameSIRPα Immune Checkpoint Therapy
FunctionCD47 is a transmembrane protein that acts as a "don't eat me" signal by binding to SIRPα on macrophages and other phagocytic cells.
Primary Expressionvarious brain regions and cell types, where it contributes to cellular signaling, gene regulation, and homeostasis
Amino Acids323 aa
PathwaysAdaptive Immunity, Amyloid, Apoptosis, Complement, Endocytosis
Ensembl IDENSG00000196776
GeneCardsCD47
Human Protein AtlasCD47
Associated DiseasesAging, Als, Alzheimer, Cancer, Glioblastoma
InteractionsAKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, ASTROCYTE
KG Connections384 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (40)

Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Complement C1q Mimetic Decoy Therapy
Score: 0.69
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Ocular Immune Privilege Extension
Score: 0.69
Ganglioside Rebalancing Therapy
Score: 0.69
Hypocretin-Neurogenesis Coupling Therapy
Score: 0.69
R-Loop Resolution Enhancement Therapy
Score: 0.68
Arginine Methylation Enhancement Therapy
Score: 0.65
Glial Glycocalyx Remodeling Therapy
Score: 0.65
HCN1-Mediated Resonance Frequency Stabilization Therapy
Score: 0.65
TREM2-Dependent Microglial Senescence Transition
Score: 0.62
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
APOE Isoform Conversion Therapy
Score: 0.72
Cholesterol-CRISPR Convergence Therapy for Neurodegeneration
Score: 0.62
Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.55
Miro1-Mediated Mitochondrial Trafficking Enhancement Therapy
Score: 0.55
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47
← Prevpg 2/2

Related Analyses (27)

Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · completed
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (9)

Protein expression analysis and cell migration assays in car
exploratory · proposed · Score: 0.88
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
RBG treatment in ApoE-/- atherosclerosis mouse model
validation · proposed · Score: 0.90
Leukocyte gene expression analysis in COVID-19 patients
exploratory · proposed · Score: 0.90
TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.45

See Also (15)

Antibody Therapy in Neurodegeneration
mechanism · Pages share 3 hypotheses
Axon Guidance Pathways in Neurodegeneration
mechanism · Pages share 3 hypotheses
Convergent Pathways in Neurodegeneration
mechanism · Pages share 3 hypotheses
COVID-19 Neurodegeneration Mechanism
mechanism · Pages share 3 hypotheses
Down Syndrome Neurodegeneration Pathway
mechanism · Pages share 3 hypotheses

Knowledge Graph (2 edges)

ent-gene-f3a46d3d data_in benchmark_ot_ad_answer_key:CD47
benchmark_ot_ad_answer_key:CD47 data_in ent-gene-f3a46d3d

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