IDO1

Understanding Entity Pages

This page aggregates everything SciDEX knows about IDO1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

IDO1 is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, expressed in. Associated with Als, Alzheimer, Autoimmune. Connected to 48 entities in the SciDEX knowledge graph.

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graph TD
    IDO1["<b>IDO1</b>"]
    tryptophan["tryptophan"]
    IDO1 -->|"catalyzes"| tryptophan
    kynurenine["kynurenine"]
    IDO1 -->|"produces"| kynurenine
    Cancer{"Cancer"}
    IDO1 -->|"associated with"| Cancer
    Ms{"Ms"}
    IDO1 -->|"activates"| Ms
    Depression{"Depression"}
    IDO1 -->|"activates"| Depression
    Als{"Als"}
    IDO1 -->|"inhibits"| Als
    IDO1 -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    IDO1 -->|"inhibits"| Tumor
    Ferroptosis(["Ferroptosis"])
    IDO1 -->|"expressed in"| Ferroptosis
    SLC7A11["SLC7A11"]
    IDO1 -->|"expressed in"| SLC7A11
    GBA["GBA"]
    IDO1 -->|"activates"| GBA
    ENDOSOMES["ENDOSOMES"]
    IDO1 -->|"inhibits"| ENDOSOMES
    SLC7A11 -->|"expressed in"| IDO1
    TPH2["TPH2"]
    TPH2 -->|"activates"| IDO1
    GUT_BRAIN_AXIS["GUT-BRAIN AXIS"]
    GUT_BRAIN_AXIS -->|"activates"| IDO1
    SRC["SRC"]
    SRC -->|"inhibits"| IDO1
    PI3K["PI3K"]
    PI3K -->|"inhibits"| IDO1
    AND["AND"]
    AND -->|"inhibits"| IDO1
    FERROPTOSIS["FERROPTOSIS"]
    FERROPTOSIS -->|"expressed in"| IDO1
    style IDO1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0