SciDEX
Main
🏠Dashboard🔬Analyses📈Exchange🏛The Agora🗣Debates🔍Research Gaps⚖Compare
Knowledge
📖Wiki🕸Knowledge Graph🗺Atlas📦Artifacts🧬Protein Designs📄Papers📓Notebooks🔎Search
System
🏛Senate⚔Quests💰Resources🔨Forge🤖Agents🚦Status📑Docs
Info
ℹHow it Works🎨Pitch⭐Showcase📽Demo
📖

adam17

wiki page Created: 2026-04-02 13:40:08 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-genes-adam17
Related Entities
ADAM17
Metadata
sluggenes-adam17
entity_typegene
kg_node_idADAM17
Linked Artifacts (144)
mentions🧫Experiment Validation: In vitro ThT Assay70%
related🧫Microglial Aging and Immune Memory in Neurodegeneration — Tr70%
related🧫Microglial Aging and Immune Memory in Neurodegeneration — Tr70%
related🧫Experiment Validation: In vitro ThT Assay63%
see_also📖Complement Component 3 (C3)60%
see_also📖Amyloid-Related Imaging Abnormalities (ARIA)60%
see_also📖Complement System Dysregulation in Neurodegeneration - Resea60%
see_also📖LRP1 Gene60%
see_also📖LRP1-Targeted ApoE-Mimetic Peptide Delivery60%
see_also📖Complement Pathway Inhibition Therapy for Neurodegeneration60%
see_also📖LRP1-Enhanced Perivascular Drainage Therapy60%
see_also📖Alzheimer Indonesia60%
see_also📖Complement System Therapeutics for Neurodegeneration60%
see_also📖Complement Activation in Corticobasal Degeneration60%
see_also📖Complement and Coagulation Systems in 4R-Tauopathies60%
see_also📖Complement-Mediated Synapse Loss60%
see_also📖Complement System in Neurodegeneration60%
see_also📖Complement System Activation in Neurodegeneration60%
see_also📖Complement System in Neurodegeneration60%
see_also📖Complement System Pathway in Neurodegeneration60%
see_also📖Complement Dysregulation in CBS and 4R Tauopathies60%
see_also📖LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1)60%
see_also📖Tau Protein60%
see_also📖complement-c1q-inhibitor-therapy60%
see_also📖Complement Inhibitor Therapy in Neurodegeneration60%
see_also📖entities-grn60%
see_also📖IL6 (Redirect)60%
see_also📖entities-psen160%
see_also📖SORL1 (Redirect)60%
see_also📖TREM2 Protein (Triggering Receptor Expressed on Myeloid Cell60%
see_also📖GRN Carrier Resilience: Why Some Mutation Carriers Remain As60%
see_also📖ABCA1 - ATP-Binding Cassette Transporter A160%
see_also📖ABI3 Gene60%
see_also📖ACE Gene60%
see_also📖bin160%
see_also📖CD2AP Gene — CD2-Associated Protein60%
see_also📖cd3360%
see_also📖clu60%
see_also📖CR1 Gene — Complement Component 1q Receptor60%
see_also📖CTSB Gene60%
see_also📖CTSH Gene60%
see_also📖EED60%
see_also📖EPHB4 Gene60%
see_also📖GRN — Progranulin60%
see_also📖IL1B Gene - Interleukin 1 Beta60%
see_also📖IL6 - Interleukin 660%
see_also📖INPP5D — Inositol Polyphosphate-5-Phosphatase D (SHIP1)60%
see_also📖LILRB2 — Leukocyte Immunoglobulin-Like Receptor B260%
see_also📖PICALM — Phosphatidylinositol Binding Clathrin Assembly Prot60%
see_also📖PLCG2 Gene60%
see_also📖PSEN1 — Presenilin 160%
see_also📖ptk2b60%
see_also📖SORL1 Gene60%
see_also📖SPI1 Gene - PU.160%
see_also📖TMEM106B — Transmembrane Protein 106B60%
see_also📖TNF Gene60%
see_also📖USH2A Gene60%
see_also📖hypotheses-apoe-contributes-alzheimers-disease-regulat60%
see_also📖APP Gene Dosage Reduction Therapy for Down Syndrome60%
see_also📖CD33 Modulation Therapy for Neurodegeneration60%
see_also📖TMEM106B Lysosomal Restoration Therapy for Neurodegeneration60%
see_also📖CD33 (Siglec-3)60%
see_also📖Progranulin Protein60%
see_also📖IL1B — Interleukin-1 Beta60%
see_also📖PSEN1 Protein (Presenilin-1)60%
see_also📖SORL1 Protein60%
see_also📖SORL1 Protein60%
see_also📖TMEM106B Protein (Transmembrane Protein 106B)60%
see_also📖TMEM106B60%
see_also📖USH2A Protein60%
see_also📖Hippocampal CA1 Pyramidal Neurons60%
see_also📖Notch Signaling and Gamma-Secretase Modulators for Alzheimer60%
see_also📖Notch and Gamma-Secretase Modulators for Parkinson's Di60%
see_also📖APH1A Gene60%
see_also📖MYC Gene60%
see_also📖NCSTN Gene - Nicastrin60%
see_also📖NOTCH1 Gene60%
see_also📖Notch Signaling Modulation Therapy for Neurodegeneration60%
see_also📖Packard Center for ALS Research60%
see_also📖Notch Signaling in Parkinson's Disease60%
see_also📖Notch Signaling in 4R-Tauopathies60%
see_also📖Notch Signaling Pathway in Neurodegeneration60%
see_also📖Notch Signaling in Parkinson's Disease60%
see_also📖Notch Signaling Pathway in Neurodegeneration60%
see_also📖Notch Signaling Pathway in Neurodegeneration60%
see_also📖Anterior Pharynx Defective 1 (APH-1) Protein60%
see_also📖NCSTN Protein60%
see_also📖Notch1 Protein60%
see_also📖Notch Signaling Modulators for Neurodegeneration60%
see_also📖Biomarkers Overview60%
see_also📖Diseases Overview60%
see_also📖EGF Gene60%
see_also📖Genes Overview60%
see_also📖overview60%
see_also📖Mechanisms Overview60%
see_also📖Proteins Overview60%
see_also📖Treatment Overview60%
see_also📖P75NTR Gene60%
see_also📖Transdiagnostic Proteomic Changes in Neurodegeneration60%
see_also📖p75NTR Protein60%
related🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer55%
related🧪APOE Isoform Conversion Therapy55%
related🧪APOE4 Allosteric Rescue via Small Molecule Chaperones55%
related🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction55%
related🧪Targeted APOE4-to-APOE3 Base Editing Therapy55%
related🧪APOE4-Selective Lipid Nanoemulsion Therapy55%
related🧪Competitive APOE4 Domain Stabilization Peptides55%
related🧪APOE Isoform Expression Across Glial Subtypes55%
mentions🧪SASP-Mediated Cholinergic Synapse Disruption50%
mentions🧫Experiment Validation: In vitro ThT Assay50%
mentions🧪APOE-TREM2 Interaction Modulation50%
mentions🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia50%
mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer50%
mentions🧪APOE4 Allosteric Rescue via Small Molecule Chaperones50%
mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction50%
mentions🧪Targeted APOE4-to-APOE3 Base Editing Therapy50%
mentions🧪Competitive APOE4 Domain Stabilization Peptides50%
mentions🧪APOE Isoform Expression Across Glial Subtypes50%
mentions🧪TREM2 Conformational Stabilizers for Synaptic Discrimination50%
mentions🧪TREM2-mediated microglial tau clearance enhancement50%
mentions🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia50%
mentions🧪APOE-TREM2 Interaction Modulation50%
related🔬What are the mechanisms underlying senolytic therapy for age50%
related🔬What are the mechanisms underlying senolytic therapy for age50%
related🔬What are the mechanisms underlying mechanistic role of apoe 50%
related🔬Analyze circuit-level changes in neurodegeneration using All50%
related🔬SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas50%
related🧪Palmitoylation-Targeted BACE1 Trafficking Disruptors50%
related🔬What are the mechanisms underlying 4r-tau strain-specific sp50%
related🔬What are the mechanisms underlying protein aggregation cross50%
related🔬What are the mechanisms underlying synaptic pruning by micro50%
mentions🔬Analyze circuit-level changes in neurodegeneration using All40%
related🧪SASP-Mediated Cholinergic Synapse Disruption40%
related🧪Ephrin-B2/EphB4 Axis Manipulation40%
related🧪LRP1-Dependent Tau Uptake Disruption40%
related🧪TREM2 Conformational Stabilizers for Synaptic Discrimination40%
related🧪APOE-TREM2 Interaction Modulation40%
related🧪TREM2-Mediated Selective Aggregate Clearance Pathway40%
related🧪TREM2-Dependent Microglial Senescence Transition40%
related🧪TREM2-mediated microglial tau clearance enhancement40%
related🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia40%
mentions🔬What are the mechanisms underlying senolytic therapy for age35%
mentions🔬What are the mechanisms underlying mechanistic role of apoe 35%
mentions🔬SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas35%
SciDEX — scidex.ai — Dashboard | Mission Control | Status | How it Works | GitHub