protein

ADAM17

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ADAM17: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

175Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	ADAM17
Chromosome	2p25.1
Function	is a transmembrane zinc-dependent metalloproteinase that functions as the primary alpha-secretase for amyloid precursor protein (APP) processing.
Exons	22
Pathways	Notch, Apoptosis, Stem Cell, Phagocytosis, Amyloid
GeneCards	ADAM17
Human Protein Atlas	ADAM17
TIMP3	Inhibitor
TIMP1	Inhibitor
RACK1	Adaptor
MAD2	Adaptor
Associated Diseases	Cancer, Neurodegeneration
Interactions	TAU, LRP1, APOE, IL6, TREM2, APP
KG Connections	175 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ADAM17["ADAM17"] -->|"activates"| TNF_alpha["TNF-alpha"]
    style TNF_alpha fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ADAM17["ADAM17"] -->|"activates"| EGFR_ligands["EGFR ligands"]
    style EGFR_ligands fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ADAM17["ADAM17"] -->|"regulates"| epithelial_tissue_development["epithelial tissue development"]
    style epithelial_tissue_development fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    ADAM17["ADAM17"] -->|"regulates"| p75NTR["p75NTR"]
    style p75NTR fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ADAM17["ADAM17"] -->|"regulates"| tPA["tPA"]
    style tPA fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ADAM17["ADAM17"] -->|"regulates"| fibrin["fibrin"]
    style fibrin fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ADAM17["ADAM17"] -->|"regulates"| nerve_conduction_velocity["nerve_conduction_velocity"]
    style nerve_conduction_velocity fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    PDK1["PDK1"] -->|"regulates"| ADAM17["ADAM17"]
    style PDK1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ERK1_2["ERK1/2"] -->|"regulates"| ADAM17["ADAM17"]
    style ERK1_2 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    RSK2["RSK2"] -->|"regulates"| ADAM17["ADAM17"]
    style RSK2 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    iRhom2["iRhom2"] -->|"regulates"| ADAM17["ADAM17"]
    style iRhom2 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    APOPTOSIS["APOPTOSIS"] -->|"expressed in"| ADAM17["ADAM17"]
    style APOPTOSIS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style ADAM17 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (119)

Target	Relation	Type	Str
TNF-alpha	activates	protein	0.90
EGFR ligands	activates	protein	0.90
epithelial tissue development	regulates	phenotype	0.90
p75NTR	regulates	receptor	0.80
tPA	regulates	enzyme	0.80
fibrin	regulates	chemical	0.80
nerve_conduction_velocity	regulates	phenotype	0.80
macrophage_recruitment	regulates	biological_process	0.80
cognitive_function	regulates	phenotype	0.70
endothelium-dependent_vasodilation	regulates	biological_process	0.70
APP	inhibits	gene	0.65
APP	activates	gene	0.65
Cancer	expressed_in	disease	0.65
Leukemia	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Cancer	implicated_in	disease	0.65
Neurodegeneration	implicated_in	disease	0.65
Alzheimer	activates	disease	0.65
DAM microglia	expressed_in	cell_type	0.65
NOTCH1	expressed_in	gene	0.60
PSEN1	expressed_in	gene	0.60
APH1	expressed_in	gene	0.60
NCSTN	expressed_in	gene	0.60
MYC	expressed_in	gene	0.60
EGF	implicated_in	gene	0.60
OVERVIEW	implicated_in	gene	0.60
APOE	associated_with	entity	0.60
APP	associated_with	entity	0.60
BIN1	associated_with	entity	0.60
CD2AP	associated_with	entity	0.60
CD33	associated_with	entity	0.60
CR1	associated_with	entity	0.60
CTSB	associated_with	entity	0.60
CTSH	associated_with	entity	0.60
EED	associated_with	entity	0.60
GRN	associated_with	entity	0.60
INPP5D	associated_with	entity	0.60
LILRB2	associated_with	entity	0.60
PICALM	associated_with	entity	0.60
PLCG2	associated_with	entity	0.60
PSEN1	associated_with	entity	0.60
PTK2B	associated_with	entity	0.60
SORL1	associated_with	entity	0.60
SPI1	associated_with	entity	0.60
TMEM106B	associated_with	entity	0.60
TREM2	associated_with	entity	0.60
CLU	associated_with	gene	0.60
ABI3	associated_with	gene	0.60
TAU	activates	gene	0.60
LRP1	activates	gene	0.60

Incoming (56)

Source	Relation	Type	Str
h-trem2-fe8c644a	targets_gene	hypothesis	0.90
PDK1	regulates	gene	0.70
RSK2	regulates	protein	0.70
iRhom2	regulates	protein	0.70
ERK1/2	regulates	protein	0.70
ABCA1	associated_with	entity	0.60
ABI3	associated_with	entity	0.60
CTSH	associated_with	gene	0.60
PTK2B	associated_with	gene	0.60
CD2AP	associated_with	gene	0.60
APOE	associated_with	gene	0.60
CR1	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
LILRB2	associated_with	gene	0.60
ACE	associated_with	gene	0.60
PLCG2	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
CLU	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
CD33	associated_with	gene	0.60
LRP1	activates	gene	0.60
SPI1	associated_with	gene	0.60
APP	associated_with	gene	0.60
INPP5D	associated_with	gene	0.60
GRN	associated_with	gene	0.60
TMEM106B	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
EED	associated_with	gene	0.60
TAU	activates	gene	0.60
IL1B	associated_with	gene	0.60
TNFA	associated_with	gene	0.60
USH2A	associated_with	gene	0.60
EPHB4	associated_with	gene	0.60
IL6	associated_with	gene	0.60
ABCA1	implicated_in	gene	0.60
ABI3	implicated_in	gene	0.60
ACE	implicated_in	gene	0.60
ADAM10	targets	gene	0.60
ADAM10	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
NEURODEGENERATION	implicated_in	gene	0.60
AMYLOID	activates	gene	0.60
PHAGOCYTOSIS	associated_with	gene	0.60
COMPLEMENT	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
ITGB8	associated_with	gene	0.60
GENES	associated_with	gene	0.60
AND	associated_with	gene	0.60
ANGPTL4	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ADAM17

Understanding Entity Pages

Wiki Pages (21)

adam17

Beta-Secretase (BACE1) Protein

Amyloid-Beta Aggregation and Plaque Formation

Tumor Necrosis Factor Alpha (TNF-α) as a Neurodegenerative Disease Biomarker

TREM2 Signaling in Neurodegeneration

APP→Amyloid-beta→Plaque→Alzheimer's Disease Causal Chain

NICASTRIN Gene

Amyloid-Beta (Aβ)

TNF Signaling Pathway in Neurodegeneration

Irisin (FNDC5) - Exercise-Induced Myokine for Neurodegeneration

Neuritic Plaques

USH2A Protein

ADAM15 Protein

APP Protein

Expanded to 3000+ words

Efferocytosis in Neurodegeneration

amyloid-cascade-hypothesis

Chemokine Signaling Pathway in Neurodegeneration

Oxytocin Receptor Modulators in Neurodegeneration